Evidence map›Paper›PMID 29255002›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain.

Yan Li, Robert Y North, Laurence D Rhines, Claudio Esteves Tatsui, Ganesh Rao, Denaya D Edwards, Ryan M Cassidy, Daniel S Harrison, Caj A Johansson, Hongmei Zhang and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 1 synthesis or guideline pooled it, 244 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
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  6. NaThe Journal of comparative neurology · 2026
    Article
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  9. RNA-binding protein MBNL2 mitigates neuropathic pain after chemotherapy through destabilizing CCR2 expression in primary sensory neurons.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  10. Article
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  12. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  13. Article
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  16. International journal of molecular sciences · 2025
    Article
  17. Article
  18. Article
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  20. Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Yan LiDepartments of Anesthesia and Pain Medicine.ORCID 0000-0002-6857-9464
Robert Y NorthDepartment of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030.
Laurence D RhinesNeurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.ORCID 0000-0002-8474-1521
Claudio Esteves TatsuiNeurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.ORCID 0000-0002-3615-0268
Ganesh RaoNeurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Denaya D EdwardsPhiladelphia College of Osteopathic Medicine, Suwanee, Georgia 30024.
Ryan M CassidyThe University of Texas Health Science Center, Houston, Texas 77030, and.ORCID 0000-0003-4100-0413
Daniel S HarrisonDuke University School of Medicine, Durham, North Carolina 27710.ORCID 0000-0001-5381-9878
Caj A JohanssonThe University of Texas Health Science Center, Houston, Texas 77030, and.ORCID 0000-0002-4130-0478
Hongmei ZhangDepartments of Anesthesia and Pain Medicine.ORCID 0000-0001-8300-3191
Patrick M DoughertyDepartments of Anesthesia and Pain Medicine, pdougherty@mdanderson.org.ORCID 0000-0002-2177-2734
Pain and Rehabilitation Medicine · USThe University of Texas MD Anderson Cancer Center · USThe University of Texas Health Science Center · USBaylor College of Medicine · USDuke University · USPhiladelphia College of Osteopathic Medicine · US

Funding

Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
The role of ENF loss, TLR4 and spinal plasticity in paclitaxel CIPNR01CA200263 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DOUGHERTY, PATRICK M · 2016 to 2020
$2.4M
Center for Clinical and Translational Sciences (CCTS)TL1TR000369 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$1.9M
NCATS NIH HHS TL1 TR000369NCATS NIH HHS UL1 TR000371NCI NIH HHS R01 CA200263
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated sodium channel 1.7 (Na

Indexed as

Action PotentialsAnimalsAntineoplastic Agents, PhytogenicCalcitonin Gene-Related PeptideFemaleGanglia, SpinalHumansHyperalgesiaMaleNAV1.7 Voltage-Gated Sodium ChannelNeuralgiaPaclitaxelPatch-Clamp TechniquesPrimary Cell CultureRatsRats, Sprague-DawleyAntineoplastic Agents, PhytogenicCalcitonin Gene-Related PeptideNAV1.7 Voltage-Gated Sodium ChannelPaclitaxelProTx-II peptideSCN9A protein, humanScn9a protein, ratSodium Channel BlockersSpider Venomscancerpainpatch clampspontaneous activity

Identifiers

PMID29255002
PMCPMC5792474
OpenAlexW2779347386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.