Evidence map›Paper›PMID 29254976›Full record

ReviewCold Spring Harbor perspectives in biology2018

Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Vaccination Strategies Based on NK Cell and ILC Memory.

Megan A Cooper, Todd A Fehniger, Marco Colonna

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Innate immunological memory: from plants to animals.Current opinion in immunology · 2020
    Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Megan A CooperDepartment of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri 63110.
Todd A FehnigerDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110.

Funding

TRANSLATING NK CELL BIOLOGY INTO CLINICAL CANCER IMMUNOTHERAPYR01CA205239 · NCI · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2017 to 2020
$2.4M
METABOLIC REGULATION OF NATURAL KILLER CELL ACTIVATIONR01AI127752 · NIAID · WASHINGTON UNIVERSITY · PI COOPER, MEGAN ANNE · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA205239NIAID NIH HHS R01 AI127752
6 · The paper itself

Abstract

Studies over the last decade have decisively shown that innate immune natural killer (NK) cells exhibit enhanced long-lasting functional responses following a single activation event. With the increased recognition of memory and memory-like properties of NK cells, questions have arisen with regard to their ability to effectively mediate vaccination responses in humans. Moreover, recently discovered innate lymphoid cells (ILCs) could also potentially exhibit memory-like functions. Here, we review different forms of NK cell memory, and speculate about the ability of these cells and ILCs to meaningfully contribute to vaccination responses.

Indexed as

VaccinationHumansImmunologic MemoryKiller Cells, NaturalLymphocytes

Identifiers

PMID29254976
PMCPMC6169813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.