Evidence map›Paper›PMID 29254951›Full record

ArticleMolecular systems biology2017

Landscape of nuclear transport receptor cargo specificity.

Marie-Therese Mackmull, Bernd Klaus, Ivonne Heinze, Manopriya Chokkalingam, Andreas Beyer, Robert B Russell, Alessandro Ori, Martin Beck

Open access · goldAbstract read
In one paragraph

Article in Molecular systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 122 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Nuclear trafficking ofVirus evolution · 2025
    Article
  13. Therapeutic targeting of exportin-1 beyond nuclear export.Trends in pharmacological sciences · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Thermal Stress and Nuclear Transport.Advances in experimental medicine and biology · 2024
    Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Marie-Therese MackmullStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0003-2928-1144
Bernd KlausCentre for Statistical Data Analysis, European Molecular Biology Laboratory, Heidelberg, Germany.
Ivonne HeinzeLeibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany.
Manopriya ChokkalingamCellular Networks and Systems Biology, CECAD, University of Cologne, Cologne, Germany.
Andreas BeyerCellular Networks and Systems Biology, CECAD, University of Cologne, Cologne, Germany.ORCID 0000-0002-3891-2123
Robert B RussellHeidelberg University Biochemistry Centre & Bioquant, Heidelberg, Germany.
Alessandro OriLeibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany alessandro.ori@leibniz-fli.de martin.beck@embl.de.ORCID 0000-0002-3046-0871
Martin BeckStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany alessandro.ori@leibniz-fli.de martin.beck@embl.de.ORCID 0000-0002-7397-1321
European Molecular Biology Laboratory · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEUniversity of Cologne · DEHeidelberg University · DE

Funding

European Research Council 309271
6 · The paper itself

Abstract

Nuclear transport receptors (NTRs) recognize localization signals of cargos to facilitate their passage across the central channel of nuclear pore complexes (NPCs). About 30 different NTRs constitute different transport pathways in humans and bind to a multitude of different cargos. The exact cargo spectrum of the majority of NTRs, their specificity and even the extent to which active nucleocytoplasmic transport contributes to protein localization remains understudied because of the transient nature of these interactions and the wide dynamic range of cargo concentrations. To systematically map cargo-NTR relationships

Indexed as

Active Transport, Cell NucleusBiotinylationCell NucleusGene OntologyHumansMutationNuclear Localization SignalsPeptidesProtein BindingProtein SubunitsProteomeReceptors, Cytoplasmic and NuclearReproducibility of ResultsRNA, Small InterferingStatistics as TopicSubcellular FractionsNuclear Localization SignalsPeptidesProtein SubunitsProteomeReceptors, Cytoplasmic and NuclearRNA, Small Interferinginteraction networknuclear pore complexprotein transportproteomicsproximity ligation

Identifiers

PMID29254951
PMCPMC5740495
OpenAlexW2781469753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.