ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2018
Somatosensory Evoked Potentials and Central Motor Conduction Times in children with dystonia and their correlation with outcomes from Deep Brain Stimulation of the Globus pallidus internus.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update.Developmental medicine and child neurology · 2024Guideline
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- Preterm birth is associated with dystonic features and reduced cortical parvalbumin immunoreactivity in mice.Pediatric research · 2025Article
- Outcomes of deep brain stimulation surgery in the management of dystonia in glutaric aciduria type 1.Journal of neurology · 2025Article
- Motor and sensory neurophysiology in relation to [Brain communications · 2025Article
- Mice born preterm develop gait dystonia and reduced cortical parvalbumin immunoreactivity.bioRxiv : the preprint server for biology · 2024Article
- Cross-frequency cortex-muscle interactions are abnormal in young people with dystonia.Brain communications · 2024Article
- Metabolic patterns in brain 18F-fluorodeoxyglucose PET relate to aetiology in paediatric dystonia.Brain : a journal of neurology · 2023Observational
- Dystonia in Childhood: How Insights from Paediatric Research Enrich the Network Theory of Dystonia.Advances in neurobiology · 2023Article
- Neurocraft: software for microscale brain network dynamics.Scientific reports · 2021Article
- Dystonia Management: What to Expect From the Future? The Perspectives of Patients and Clinicians Within DystoniaNet Europe.Frontiers in neurology · 2021Review
- Sensorimotor Integration in Childhood Dystonia and Dystonic Cerebral Palsy-A Developmental Perspective.Frontiers in neurology · 2021Review
- Rehabilitation Evaluation of Hemiplegic Patients with Anterior Circulation Cerebral Infarction Based on Cranial Magnetic Stimulation.Journal of healthcare engineering · 2021Article
- Abnormal microscale neuronal connectivity triggered by a proprioceptive stimulus in dystonia.Scientific reports · 2020Article
- Application of Machine Learning Using Decision Trees for Prognosis of Deep Brain Stimulation of Globus Pallidus Internus for Children With Dystonia.Frontiers in neurology · 2020Article
- Neurophysiological insights in dystonia and its response to deep brain stimulation treatment.Experimental brain research · 2020Review
- Abnormal patterns of corticomuscular and intermuscular coherence in childhood dystonia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Cognitive Strategy Training in Childhood-Onset Movement Disorders: Replication Across Therapists.Frontiers in pediatrics · 2020Article
- Recent advances in understanding and managing dystonia.F1000Research · 2018Review
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10 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesTo report Somatosensory Evoked Potentials (SEPs) and Central Motor Conduction Times (CMCT) in children with dystonia and to test the hypothesis that these parameters predict outcome from Deep Brain Stimulation (DBS).
methods180 children with dystonia underwent assessment for Globus pallidus internus (GPi) DBS, mean age 10 years (range 2.5-19). CMCT to each limb was calculated using Transcranial Magnetic Stimulation. Median and posterior tibial nerve SEPs were recorded over contralateral and midline centro-parietal scalp. Structural abnormalities were assessed with cranial MRI. One-year outcome from DBS was assessed as percentage improvement in Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-m).
resultsAbnormal CMCTs and SEPs were found in 19% and 47% of children respectively and were observed more frequently in secondary than primary dystonia. Of children proceeding to DBS, better outcome was seen in those with normal (n = 78/89) versus abnormal CMCT (n = 11/89) (p = 0.002) and those with normal (n = 35/51) versus abnormal SEPs (n = 16/51) (p = 0.001). These relationships were independent of dystonia aetiology and cranial MRI findings.
conclusionsCMCTs and SEPs provide objective evidence of motor and sensory pathway dysfunction in children with dystonia and relate to DBS outcome. SIGNIFICANCE: CMCTs and SEPs can contribute to patient selection and counselling of families about potential benefit from neuromodulation for dystonia.
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