Evidence map›Paper›PMID 29254793›Full record

ArticlePathology, research and practice2018

Immunophenotypic profile of tumor buds in breast cancer.

C Laedrach, B Salhia, N Cihoric, I Zlobec, C Tapia

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathology, research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021
    Review
  7. Article
  8. Review
  9. HER2 in stemness and epithelial-mesenchymal plasticity of breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019
    Review
  10. Prognostic role of tumor budding in breast cancer.World journal of experimental medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

C LaedrachIntstitute of Pathology, University of Bern, Bern, Switzerland.
B SalhiaDepartment of Translational Genomics, Keck School of Medicine of USC, Los Angeles, CA, USA.
N CihoricDepartment of Radio-Oncology, Inselspital, Bern, Switzerland; Breast Center, Inselspital, Bern, Switzerland.
I ZlobecIntstitute of Pathology, University of Bern, Bern, Switzerland.
C TapiaIntstitute of Pathology, University of Bern, Bern, Switzerland; Breast Center, Inselspital, Bern, Switzerland; Department of Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX, USA; Department of Investigational Cancer Therapeutics, UT MD Anderson Cancer Center, Houston, TX, USA. Electronic address: CTapia1@mdanderson.org.
University of Bern · CHBreast Center · CH

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

backgroundTumor buds are associated with lympho-vascular invasion and lymph node metastases leading to the assumption that they are involved in the early metastatic process. Hence, it would be important to know if tumor buds can be targeted with the most widely used targeted therapies in breast cancer (BC) and if changes in hormone and Her2 status occur. The aim of this study was to answer these questions by determining whether hormone receptor (HR) and Her2 status are expressed in the tumor buds of a large cohort of BCs.

designWe constructed a tumor bud next-generation tissue microarray (ngTMA) consisting of n = 199 BCs of non-special type. Generally, two 1 mm punches were taken from the tumor bud areas in the periphery (PTB) and within the tumor center (ITB). HR and Her2 status was assessed using immunohistochemistry and fluorescence in situ hybridization, respectively. HR status was positive if ≥1% of tumor bud cells were positive. Her2 status was considered positive if bud cells showed strong complete membranous Her2 over-expression or Her2 amplification.

resultsMost tumor buds were positive for estrogen (ER) (PTB: 86%; ITB: 88.3) and progesterone receptor (PgR) (PTB: 72%; ITB: 72.8%) and Her2 was positive in: PTB 11.5% and ITB 11%. A difference between the main tumor mass and tumor buds (PTB and ITB) was seen for PgR in 3.5% of cases (n = 7). No differences were seen for ER and Her2 between tumor buds and main tumor mass.

conclusionMost tumor buds (96.5%) share the same HR and Her2 expression profile of the main tumor mass, implying that tumor buds relay on the same pathways as the main tumor mass and might be equally responsive to targeted therapies.

Indexed as

ImmunophenotypingAdultAgedAged, 80 and overBiopsyBreast NeoplasmsCarcinoma, Ductal, BreastFemaleHumansLymphatic MetastasisMammary Glands, HumanMiddle AgedBreast cancerHer2Hormone receptorsTumor budding

Identifiers

PMID29254793
PMCPMC7474545
OpenAlexW2772396739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.