Evidence map›Paper›PMID 29254505›Full record

ArticleJournal for immunotherapy of cancer2017

Anti-PD-1 Vasculitis of the central nervous system or radionecrosis?

Roger Sun, Francois-Xavier Danlos, Samy Ammari, Guillaume Louvel, Frédéric Dhermain, Stéphane Champiat, Olivier Lambotte, Eric Deutsch

Open access · goldAbstract readEditorialComment
In one paragraph

Article in Journal for immunotherapy of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Roger SunDepartment of Radiotherapy, Gustave Roussy Cancer Campus, 94800, Villejuif, France.
Francois-Xavier DanlosImmunity and Cancer Department, Institut Curie, PSL Research University, Institut National de la Santé et de la Recherche Médicale U932, 75005, Paris, France.
Samy AmmariDepartment of Radiology, Gustave Roussy Cancer Campus, 94800, Villejuif, France.
Guillaume LouvelDepartment of Radiotherapy, Gustave Roussy Cancer Campus, 94800, Villejuif, France.
Frédéric DhermainDepartment of Radiotherapy, Gustave Roussy Cancer Campus, 94800, Villejuif, France.
Stéphane ChampiatDrug Development Department, Gustave Roussy Cancer Campus, 94800, Villejuif, France.
Olivier LambotteDepartment of Internal Medicine, Bicêtre Hopistal, 94270, Le Kremlin-Bicêtre, France.
Eric DeutschDepartment of Radiotherapy, Gustave Roussy Cancer Campus, 94800, Villejuif, France. eric.deutsch@gustaveroussy.fr.
Institut Gustave Roussy · FRUniversité Paris-Saclay · FRInternational Drug Development · FRUniversité Paris Sciences et Lettres · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Commentary on « Cerebral vasculitis mimicking intracranial metastatic progression of lung cancer during PD-1 blockade » by Läubli H et al., J Immunother Cancer. 2017;5:46.The authors diagnosed a cerebral tumor-like lymphocytic vasculitis associated with anti-endothelial cell auto-antibodies secondary to anti-PD-1 therapy, treated by surgical resection and corticosteroids. We thought that this diagnosis should be discussed for at least two reasons. First, etiological explorations were not sufficient. Second, the diagnostic of radionecrosis should also be discussed.

Indexed as

Lung NeoplasmsVasculitis, Central Nervous SystemDisease ProgressionHumansProgrammed Cell Death 1 ReceptorProgrammed Cell Death 1 ReceptorCerebral vasculitisImmunotherapyRadionecrosis

Identifiers

PMID29254505
PMCPMC5735956
OpenAlexW2769848678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.