ArticleJournal of medical case reports2017
Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports.
Article in Journal of medical case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A meta-analysis of livestock brucellosis prevalence in Indonesia.The veterinary quarterly · 2024Pooled it
- Machine learning based on pangenome-wide association studies reveals the impact of host source on the zoonotic potential of closely related bacterial pathogens.Communications biology · 2025Article
- Article
- Molecular and serological survey of Brucella spp. among rodents in western Iran.BMC veterinary research · 2025Article
- Brucella microti and Rodent-Borne Brucellosis: A Neglected Public Health Threat.Zoonoses and public health · 2025Review
- Genomic Diversity and Zoonotic Potential of Brucella neotomae.Emerging infectious diseases · 2024Article
- Brucellosis in the Brazilian Pantanal wetland: threat to animal production and wildlife conservation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- Comparative proteomic analysis of outer membrane vesicles from Brucella suis, Brucella ovis, Brucella canis and Brucella neotomae.Archives of microbiology · 2021Article
- Uncovering the Hidden Credentials ofMicrobiology and molecular biology reviews : MMBR · 2021Review
- Review
- Brucella suppress STING expression via miR-24 to enhance infection.PLoS pathogens · 2020Article
- Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis.PLoS neglected tropical diseases · 2020Article
- Intracellular invasion and survival of Brucella neotomae, another possible zoonotic Brucella species.PloS one · 2019Article
- Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis SmoothFrontiers in veterinary science · 2019Article
- A MALDI-TOF MS database with broad genus coverage for species-level identification of Brucella.PLoS neglected tropical diseases · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBrucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified two brucellosis human cases caused by B. neotomae, demonstrating that this species has zoonotic potential. CASES PRESENTATION: Within almost 4 years of each other, a 64-year-old Costa Rican white Hispanic man and a 51-year-old Costa Rican white Hispanic man required medical care at public hospitals of Costa Rica. Their hematological and biochemical parameters were within normal limits. No adenopathies or visceral abnormalities were found. Both patients showed intermittent fever, disorientation, and general malaise and a positive Rose Bengal test compatible with Brucella infection. Blood and cerebrospinal fluid cultures rendered Gram-negative coccobacilli identified by genomic analysis as B. neotomae. After antibiotic treatment, the patients recovered with normal mental activities.
conclusionsThis is the first report describing in detail the clinical disease caused by B. neotomae in two unrelated patients. In spite of previous claims, this bacterium keeps zoonotic potential. Proposals to generate vaccines by using B. neotomae as an immunogen must be reexamined and countries housing the natural reservoir must consider the zoonotic risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.