Evidence map›Paper›PMID 29254212›Full record

ArticleOncotarget2017

Long noncoding RNA TUG1 is a diagnostic factor in lung adenocarcinoma and suppresses apoptosis via epigenetic silencing of BAX.

Huan Liu, Guizhi Zhou, Xin Fu, Haiyan Cui, Guangrui Pu, Yao Xiao, Wei Sun, Xinhua Dong, Libin Zhang, Sijia Cao and 3 more

RetractedOpen access · diamondAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 56 citations in OpenAlex.

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  9. Noncoding RNAs in apoptosis: identification and function.Turkish journal of biology = Turk biyoloji dergisi · 2022
    Review
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  17. Exosomal Long Non-Coding RNAs in Lung Diseases.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Huan LiuHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Guizhi ZhouHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Xin FuHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Haiyan CuiHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Guangrui PuHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Yao XiaoHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Wei SunHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Xinhua DongHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Libin ZhangHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Sijia CaoHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Guiqin LiHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Xiaowei WuHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Xu YangHealth Physical Examination Department of The Third Department, The First Affiliated hospital of Dalian Medical University, Dalian, Liaoning, China.
Dalian Medical University · CNFirst Affiliated Hospital of Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is one of the leading causes of cancer-related mortality, and responds badly to existing treatment. Thus, it is of urgent need to identify novel diagnostic markers and therapeutic targets. Increasing evidences have indicated that long non-coding RNAs (lncRNAs) play an important role in initiation and progression of lung cancer. However, the role of lncRNA Taurine upregulated 1 (TUG1) in lung adenocarcinoma (LAD) progression is not well known. In this study, we determined the diagnostic value of TUG1 in LAD patients, and further uncovered the underlying functional mechanism. Our results showed that TUG1 was significantly upregulated in LAD cells and serum samples. Receiver operator characteristic (ROC) analysis suggested a relatively higher area under the curve (AUC) of TUG1 (0.756) contrast to cyfra21-1 (0.619). In addition, high TUG1 level was associated with enhanced tumor size, degree of differentiation, lymph node metastases, distant metastasis and TNM stage. Cell functional assays showed that knockdown of TUG1 suppressed LAD cell viability and promoted cell apoptosis. We then sought to reveal the underlying regulatory mechanism, and the pro-apoptotic protein BAX was then identified as the downstream target of TUG1. Gain and loss functional assays showed that inhibition of BAX reversed the induced apoptosis by TUG1 knockdown. Finally, RNA immunoprecipitation and Chromatin immunoprecipitation revealed that TUG1 suppressed BAX expression through physically interacting with EZH2. In conclusion, lncRNA TUG1 is a promising diagnostic marker for LAD patients and suppression of TUG1 levels could be a future direction to promote the prognosis of LAD patients.

Indexed as

BAXdiagnosisEZH2lncRNA TUG1lung adenocarcinoma

Identifiers

PMID29254212
PMCPMC5731922
OpenAlexW2766547400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.