ArticleOncotarget2017
Up-regulation of RNF187 induces hepatocellular carcinoma cell epithelial to mesenchymal transitions.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- RNF187 Facilitates Proliferation and Migration of Human Spermatogonial Stem Cells Through WDR77 Polyubiquitination.Cell proliferation · 2025Article
- Functional Enrichment Analysis of Tumor Microenvironment-Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis.Bioinformatics and biology insights · 2024Article
- RACO-1 modulates Hippo signalling in oesophageal squamous cell carcinoma.Journal of cellular and molecular medicine · 2020Article
- Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187.Oncogenesis · 2020Article
- High level of RNF187 contributes to the progression and drug resistance of osteosarcoma.Journal of Cancer · 2020Article
- An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2019Article
- Overexpression of RNF187 induces cell EMT and apoptosis resistance in NSCLC.Journal of cellular physiology · 2019Article
- Oncogene Delta/Notch-Like EGF-Related Receptor Promotes Cell Proliferation, Invasion, and Migration in Hepatocellular Carcinoma and Predicts a Poor Prognosis.Cancer biotherapy & radiopharmaceuticals · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ring finger protein 187 (RNF187) has been identified to be a co-activator linking c Jun to Ras signaling. However, the expression and function of RNF187 in hepatocellular carcinomas (HCC) remains unclear. Here, we tried to determine the expression and roles of RNF187 in hepatocellular carcinomas (HCC).The expression of RNF187 was determined in HCC tissues and cell lines, and we found that RNF187 expressed highly in HCC tissues compared with the corresponding adjacent liver tissues both in mRNA and protein level, which was consistent with the result of immunohistochemistry on HCC tissue microarrays. In HCC cell lines, the level of RNF187 was positively associated with the HCC cells metastatic potential. By the RNF187 interference and cDNA transfection, we showed that the high level of RNF187 induced the HCC cells invasion and metastasis both
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Registered trials
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