Evidence map›Paper›PMID 29254197›Full record

ArticleOncotarget2017

Apelin13/APJ promotes proliferation of colon carcinoma by activating Notch3 signaling pathway.

Tong Chen, Ning Liu, Guang-Meng Xu, Tong-Jun Liu, Ying Liu, Yan Zhou, Si-Bo Huo, Kai Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Silencing APLNR enhances the radiosensitivity of prostate cancer by modulating the PI3K/AKT/mTOR signaling pathway.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  3. Apelin/APJ: Another Player in the Cancer Biology Network.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. A network map of apelin-mediated signaling.Journal of cell communication and signaling · 2022
    Article
  11. Elabela gene therapy promotes angiogenesis after myocardial infarction.Journal of cellular and molecular medicine · 2021
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tong ChenGastrointestinal Surgery Department, The China-Japan Union Hospital of Jilin University, Jilin, China.
Ning LiuGeneral Surgery Department, The First Hospital of Jilin Province Academy of Traditional Chinese Medicine, Jilin, China.
Guang-Meng XuColorectal Surgery Department, The Second Hospital of Jilin University, Jilin, China.
Tong-Jun LiuColorectal Surgery Department, The Second Hospital of Jilin University, Jilin, China.
Ying LiuColorectal Surgery Department, The Second Hospital of Jilin University, Jilin, China.
Yan ZhouColorectal Surgery Department, The Second Hospital of Jilin University, Jilin, China.
Si-Bo HuoColorectal Surgery Department, The Second Hospital of Jilin University, Jilin, China.
Kai ZhangColorectal Surgery Department, The Second Hospital of Jilin University, Jilin, China.
Second Affiliated Hospital of Jilin University · CNJilin Academy of Traditional Chinese Medicine · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe link between Apelin (APL)/APL receptor (APJ) and Jagged (JAG)/Notch signaling pathways in colorectal cancer (CRC) has been poorly investigated. APL/APJ system, a potent angiogenic factor, is up-regulated in a variety of cancers. It contributes to tumor angiogenesis, and correlates with progression of malignancy. JAG/Notch signaling also contributes to progression, proliferation and metastasis of multiple cancers, including CRC. Here we tested the hypothesis that APL/APJ system promotes CRC proliferation by up-regulating Notch3, thus allowing further binding of JAG1 to Notch3. MATERIALS AND

methodsWe used a variety of methods including Western blot, RT-qPCR, gene silencing, ELISA, immunofluorescence staining, to investigate the interaction between APL/APJ system and Notch3 signaling pathway in both surgically-resected specimens and CRC cell line LS180.

resultsWe show that the expression of APL13, APJ, and Notch3 is elevated in CRC. We further demonstrate that APL13 can be secreted into culture media of LS180 cells, suggesting the existence of autocrine loop in CRC. Moreover, we found that APL13 stimulated expression of Notch3. Finally, we found that inhibition of either APJ or Notch3 prevents proliferation of LS180 cells.

conclusionsOur results suggest that APL13/APJ and JAG1/Notch3 signaling pathways are linked in CRC. These findings provide a new direction to the efforts targeting effective therapeutic and management approaches in the treatment of CRC.

Indexed as

Apelin/APJcancer proliferationcolon carcinomaNotch3

Identifiers

PMID29254197
PMCPMC5731907
OpenAlexW2767185614

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.