Evidence map›Paper›PMID 29254156›Full record

ArticleOncotarget2017

The clinical significance of circulating GPC1 positive exosomes and its regulative miRNAs in colon cancer patients.

Jian Li, Bo Li, Caiping Ren, Yuxiang Chen, Xiong Guo, Lin Zhou, Zha Peng, Yaping Tang, Yang Chen, Weidong Liu and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Prognostic value of extracellular vesicles in colorectal cancer: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
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  20. Role of glypican-1 in regulating multiple cellular signaling pathways.American journal of physiology. Cell physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Jian LiHepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Bo LiDepartment of Pathology, Xiangya Medical School, Central South University, Changsha, Hunan 410078, China.
Caiping RenCancer Research Institute, Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Yuxiang ChenSchool of Pharmaceutical Science, Central South University, Changsha, Hunan 410013, China.
Xiong GuoHepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Lin ZhouHepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Zha PengHepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yaping TangHepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yang ChenHepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Weidong LiuCancer Research Institute, Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Bin ZhuCancer Research Institute, Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Lei WangCancer Research Institute, Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Xuxu LiuCancer Research Institute, Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Xiao ShiCancer Research Institute, Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Zixuan PengCancer Research Institute, Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Central South University · CNHunan Cancer Hospital · CNXiangya Hospital Central South University · CN

Funding

Novel therapies in alcoholic hepatitis University of LouisvilleU01AA021901 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2012 to 2017
$1.5M
Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative StressR00AA021803 · NIAAA · EMORY UNIVERSITY · PI YELIGAR, SAMANTHA M. · 2016 to 2018
$747k
Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative StressK99AA021803 · NIAAA · EMORY UNIVERSITY · PI YELIGAR, SAMANTHA M. · 2013 to 2014
$231k
NIAAA NIH HHS K99 AA021803NIAAA NIH HHS R00 AA021803NIAAA NIH HHS U01 AA021901
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Recent study found an increased level of glypican-1 positive (GPC1

Indexed as

biomarkercolorectal cancerexosomeGPC1miRNA

Identifiers

PMID29254156
PMCPMC5731866
OpenAlexW2746561055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.