ArticleJournal of Huntington's disease2017
Cognitive Dysfunction Contributes to Mobility Impairments in Huntington's Disease.
Article in Journal of Huntington's disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature.Brain and behavior · 2026Pooled it
- Does physical activity improve motor function and gait in huntington disease? A systematic review and meta-analysis.Revista de neurologia · 2022Pooled it
- The Step Test Evaluation of Performance on Stairs (STEPS): Validation and reliability in a neurological disorder.PloS one · 2019Trial
- Musical Distractions: Music-Based Rhythmic Auditory Stimulation Fails to Improve Gait in Huntington's Disease.Brain sciences · 2025Article
- Prodromal Cognitive Changes as a Prognostic Indicator of Forthcoming Huntington's Disease Severity: A Retrospective Longitudinal Study.Movement disorders clinical practice · 2024Article
- Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington's disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Behavioral- and blood-based biomarkers for Huntington's disease: Studies on the R6/1 mouse model with prospects for early diagnosis and monitoring of the disease.Brain, behavior, & immunity - health · 2022Article
- Clinical Decision Trees to Guide Physical Therapy Management of Persons with Huntington's Disease.Journal of Huntington's disease · 2022Review
- Approach to Posture and Gait in Huntington's Disease.Frontiers in bioengineering and biotechnology · 2021Review
- Astroglial connexins and cognition: memory formation or deterioration?Bioscience reports · 2020Review
- The effects of dual-task cognitive interference on gait and turning in Huntington's disease.PloS one · 2020Article
- The Effects of Dual-Task Cognitive Interference and Environmental Challenges on Balance in Huntington's Disease.Movement disorders clinical practice · 2019Article
- Cognitive-Motor Interference in Neurodegenerative Disease: A Narrative Review and Implications for Clinical Management.Frontiers in psychology · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuntington's disease (HD) is a progressive neurodegenerative disorder that results in a gradual decline in mobility and balance. Increasing evidence has documented an important role of executive function in the safe ambulation of the elderly and people with a variety of neurological disorders. Little is known about the contribution of cognitive deficits to decline in mobility over time in HD.
objectiveThis study examined the relationships of mobility, motor and cognitive function measures at baseline, and of mobility and cognitive measures over four years.
methodsA retrospective chart review was performed on 70 patients with genetically confirmed HD (age 20-75 years old) across 121 HD clinic visits. Correlations between Unified Huntington's Disease Rating Scale - Total Motor, Tinetti Mobility Test (TMT), and cognitive measures (Letter Verbal Fluency, Symbol Digit Modalities Test (SDMT), and Stroop Test) were analyzed. Longitudinal relationships between TMT and cognitive measures were examined using mixed effect regression models.
resultsGait and balance measures representing domains of mobility (TMT scores) were significantly correlated with each of the cognitive measures with the exception of the Verbal Fluency score. Mixed effects regression modeling showed that the Stroop Interference sub-test and SDMT were significant predictors (p-values <0.01) of TMT total scores.
conclusionsImpairments in executive function measures correlate highly with measures of gait, balance and mobility in individuals with HD. Interventions designed to improve mobility and decrease fall risk should also address issues of cognitive impairments with particular consideration given to interventions that may focus on motor-cognitive dual task training.
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