Evidence map›Paper›PMID 29254087›Full record

ArticleJournal of Alzheimer's disease : JAD2018

Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall.

Sheina Emrani, David J Libon, Melissa Lamar, Catherine C Price, Angela L Jefferson, Katherine A Gifford, Timothy J Hohman, Daniel A Nation, Lisa Delano-Wood, Amy Jak and 7 more

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Deconstructing delirium in the post anaesthesia care unit.Frontiers in aging neuroscience · 2022
    Article
  14. Article
  15. Article
  16. Visuospatial performance in patients with statistically-defined mild cognitive impairment.Journal of clinical and experimental neuropsychology · 2020
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sheina EmraniDepartments of Geriatrics, Gerontology and Psychology, New Jersey Institute for Successful Aging, Rowan University-School of Osteopathic Medicine, Stratford, NJ, USA.
David J LibonDepartments of Geriatrics, Gerontology and Psychology, New Jersey Institute for Successful Aging, Rowan University-School of Osteopathic Medicine, Stratford, NJ, USA.
Melissa LamarDepartment of Behavioral Sciences and the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Catherine C PriceDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Angela L JeffersonVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Katherine A GiffordVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Daniel A NationDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Lisa Delano-WoodVA San Diego Healthcare System, San Diego, CA, USA.
Amy JakVA San Diego Healthcare System, San Diego, CA, USA.
Katherine J BangenVA San Diego Healthcare System, San Diego, CA, USA.
Mark W BondiVA San Diego Healthcare System, San Diego, CA, USA.
Adam M BrickmanDepartment of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jennifer ManlyDepartment of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Rodney SwensonUniversity of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.
Rhoda AuDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Consortium for Clinical and Epidemiological Neuropsychological Data Analysis (CENDA)

Funding

VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2016 to 2026
$28.4M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUTTING, LAURIE E · 2015 to 2019
$7.1M
Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial FindingsR01AG049810 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, EDLAND, STEVEN DYAL · 2016 to 2020
$3.7M
Neuroimaging and Risk Factor Correlates in Aging and MCIK24AG026431 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W · 2007 to 2016
$1.7M
Risk factors and prevention targets for abnormal cognitive agingK24AG046373 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2014 to 2023
$1.7M
Cognitive Complaints in Aging AdultsK23AG045966 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GIFFORD, KATHERINE A. · 2015 to 2022
$960k
Genetic Resilience to the Clinical Manifestation of DementiaK01AG049164 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HOHMAN, TIMOTHY J · 2016 to 2020
$595k
Neuroimaging and Vascular Correlates of Mild Cognitive Impairment SubtypesIK2CX000938 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BANGEN, KATHERINE · 2015 to 2019
–
CSRD VA IK2 CX000938NIA NIH HHS K01 AG049164NIA NIH HHS K23 AG045966NIA NIH HHS K24 AG026431NIA NIH HHS K24 AG046373NIA NIH HHS P01 AG052350NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG049810NICHD NIH HHS K12 HD043483NICHD NIH HHS U54 HD083211
6 · The paper itself

Abstract

backgroundWorking memory (WM) is often assessed with serial order tests such as repeating digits backward. In prior dementia research using the Backward Digit Span Test (BDT), only aggregate test performance was examined.

objectiveThe current research tallied primacy/recency effects, out-of-sequence transposition errors, perseverations, and omissions to assess WM deficits in patients with mild cognitive impairment (MCI).

methodsMemory clinic patients (n = 66) were classified into three groups: single domain amnestic MCI (aMCI), combined mixed domain/dysexecutive MCI (mixed/dys MCI), and non-MCI where patients did not meet criteria for MCI. Serial order/WM ability was assessed by asking participants to repeat 7 trials of five digits backwards. Serial order position accuracy, transposition errors, perseverations, and omission errors were tallied.

resultsA 3 (group)×5 (serial position) repeated measures ANOVA yielded a significant group×trial interaction. Follow-up analyses found attenuation of the recency effect for mixed/dys MCI patients. Mixed/dys MCI patients scored lower than non-MCI patients for serial position 3 (p < 0.003) serial position 4 (p < 0.002); and lower than both group for serial position 5 (recency; p < 0.002). Mixed/dys MCI patients also produced more transposition errors than both groups (p < 0.010); and more omissions (p < 0.020), and perseverations errors (p < 0.018) than non-MCI patients.

conclusionsThe attenuation of a recency effect using serial order parameters obtained from the BDT may provide a useful operational definition as well as additional diagnostic information regarding working memory deficits in MCI.

Indexed as

Memory, Short-TermMental RecallNeuropsychological TestsAgedAged, 80 and overCognitive DysfunctionExecutive FunctionFemaleHumansMaleMemory DisordersRegression AnalysisSerial LearningBoston process approachdigit spanexecutive functionsmild cognitive impairmentserial orderworking memory

Identifiers

PMID29254087
PMCPMC5901759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.