ArticleCarbohydrate polymers2018
Immunostimulatory and anti-metastatic activity of polysaccharides isolated from byproducts of the corn starch industry.
Article in Carbohydrate polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Prebiotic and Anti-Adipogenic Effects of Radish Green Polysaccharide.Microorganisms · 2023Article
- Immunomodulatory effects of four polysaccharides purified from Erythronium sibiricum bulb on macrophages.Glycoconjugate journal · 2021Article
- Antihypertensive and Immunomodulatory Effects of Defatted Corn Germ Hydrolysates: AnFrontiers in nutrition · 2021Article
- Layers of Uranium Phosphate Nanorods and Nanoplates Encrusted on Fungus Cladosporium sp. Strain F1 Hyphae.Microbes and environments · 2021Article
- Structural characteristics of a red ginseng acidic polysaccharide rhamnogalacturonan I with immunostimulating activity from red ginseng.Journal of ginseng research · 2020Article
- Anti-Cancer Effects ofFrontiers in pharmacology · 2019Article
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4 authors.
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Abstract
Corn steep liquor (CSL) is a major by-product of the corn steeping process that is utilized in the wet milling industry. To develop new physiologically active polysaccharides from CSL, polysaccharides were isolated and their innate immunostimulatory and anti-metastatic activities were investigated. Corn byproduct polysaccharides (CBP) were preferentially isolated from CSL and further separated into supernatant (CBP1S) and precipitate (CBP1P) fractions. The anti-complementary activity of CBP1S was more potent than CBP1P and CBP. In addition, CBP1S enhanced production of macrophage-stimulating cytokines (e.g., IL-6 and IL-12) and natural killer (NK) cell-activating substances (e.g., granzyme and interferon-γ). Further, CBP1S significantly inhibited lung metastasis at a dose of 1000μg per mouse in an experimental lung metastasis model. These results suggest that CBP1S seems to promote the inhibition of lung metastasis through a mechanism leading to stimulation of the innate immune system, and CBP1S could be used as immunostimulating agents and for industrial applications.
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