Evidence map›Paper›PMID 29253516›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2018

Inducible overexpression of endothelial proNGF as a mouse model to study microvascular dysfunction.

Riyaz Mohamed, Maha Coucha, Sally L Elshaer, Sandeep Artham, Tahira Lemtalsi, Azza B El-Remessy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. The innate immune system in diabetic retinopathy.Progress in retinal and eye research · 2021
    Review
  4. Article
  5. Modulation of p75International journal of molecular sciences · 2021
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Riyaz MohamedAugusta Biomedical Research Corporation, Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.
Maha CouchaAugusta Biomedical Research Corporation, Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.
Sally L ElshaerAugusta Biomedical Research Corporation, Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.
Sandeep ArthamAugusta Biomedical Research Corporation, Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.
Tahira LemtalsiAugusta Biomedical Research Corporation, Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.
Azza B El-RemessyAugusta Biomedical Research Corporation, Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA. Electronic address: Azza.El-Remessy@va.org.
Charlie Norwood VA Medical Center · US

Funding

Molecular Mechanisms of diabetic retinopathyR01EY022408 · NEI · UNIVERSITY OF GEORGIA · PI EL-REMESSY, AZZA B · 2012 to 2016
$1.5M
NEI NIH HHS EY-0022408NEI NIH HHS R01 EY022408
6 · The paper itself

Abstract

Impaired maturation of nerve growth factor precursor (proNGF) and its accumulation has been reported in several neurodegenerative diseases, myocardial infarction and diabetes. To elucidate the direct impact of proNGF accumulation identified the need to create a transgenic model that can express fully mutated cleavage-resistant proNGF. Using Cre-Lox technology, we developed an inducible endothelial-specific proNGF transgenic mouse (proNGF

Indexed as

AnimalsDisease Models, AnimalEndothelium, VascularGene Expression RegulationKidney DiseasesMiceMice, Inbred C57BLMice, TransgenicMicrovesselsNerve Growth FactorProtein PrecursorsProtein Processing, Post-TranslationalRetinaRetinal DiseasesRetinal VesselsNerve Growth FactorProtein PrecursorsAcellular capillaryApoptosisBarrier dysfunctionDiabetic retinopathyInflammationNerve growth factorNeurodegenerationNeurotrophin

Identifiers

PMID29253516
PMCPMC6482462
OpenAlexW2771839313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.