Evidence map›Paper›PMID 29253496›Full record

ArticleJournal of virological methods2018

Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1).

Aayushi Uberoi, Satoshi Yoshida, Paul F Lambert

Open access · greenAbstract read
In one paragraph

Article in Journal of virological methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

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  14. Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk.JID innovations : skin science from molecules to population health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Aayushi UberoiMcArdle Laboratory of Cancer Research, 1111 Highland Avenue, University of Wisconsin, Madison 53705, United States.
Satoshi YoshidaMcArdle Laboratory of Cancer Research, 1111 Highland Avenue, University of Wisconsin, Madison 53705, United States.
Paul F LambertMcArdle Laboratory of Cancer Research, 1111 Highland Avenue, University of Wisconsin, Madison 53705, United States. Electronic address: plambert@wisc.edu.
University of Wisconsin–Madison · USHighland Community College - Illinois · US

Funding

Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI WILLIAM M. SUGDEN · 1985 to 2026
$53.1M
Defining Drivers of HPV-associated CarcinogenesisR35CA210807 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 2017 to 2026
$9.2M
NCI NIH HHS P01 CA022443NCI NIH HHS R35 CA210807
6 · The paper itself

Abstract

Preclinical model systems to study multiple features of the papillomavirus life cycle are extremely valuable tools to aid our understanding of Human Papillomavirus (HPV) biology, disease progression and treatments. Mouse papillomavirus (MmuPV1) is the first ever rodent papillomavirus that can infect the laboratory strain of mice and was discovered recently in 2011. This model is an attractive model to study papillomavirus pathogenesis due to the ubiquitous availability of lab mice and the fact that this mouse species is easily genetically modifiable. Several other groups, including ours, have reported that MmuPV1-induced papillomas are restricted to T-cell deficient immunosuppressed mice. In our lab we showed for the first time that MmuPV1 causes skin cancers in UVB-irradiated immunocompetent animals. In this report we describe in detail the MmuPV1-UV infection model that can be adapted to study MmuPV1 biology in immunocompetent animals.

Indexed as

AnimalsDisease Models, AnimalMicePapillomaviridaePapillomavirus InfectionsPhenotypeSkinTime FactorsViral LoadImmunocompetentMouse papillomavirusPreclinical modelUltraviolet radiation

Identifiers

PMID29253496
PMCPMC5898621
OpenAlexW2774605609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.