ArticleCerebral cortex (New York, N.Y. : 1991)2018
Inhibitory Modulation of Orbitofrontal Cortex on Medial Prefrontal Cortex-Amygdala Information Flow.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 103 citations in OpenAlex.
- Structural covariance, regional topology, and volumetric aspects of amygdala subnuclei in posttraumatic stress disorder using ultra-high field imaging.Molecular psychiatry · 2026Article
- Network-nodal tACS induces right-lateralization of thalamocortical connectivity.Scientific reports · 2026Article
- Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD.BMC psychiatry · 2025Article
- Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature.Translational psychiatry · 2024Article
- Deficits in Key Brain Network for Social Interaction in Individuals with Schizophrenia.Brain sciences · 2023Article
- Modulation of prefrontal couplings by prior belief-related responses in ventromedial prefrontal cortex.Frontiers in neuroscience · 2023Article
- Reinforcement learning detuned in addiction: integrative and translational approaches.Trends in neurosciences · 2022Review
- Upregulation of Netrin-1 in the hippocampus mediates the formation of visceral hypersensitivity induced by maternal separation.Frontiers in molecular neuroscience · 2022Article
- Convergent and Divergent Structural Connectivity of Brain White Matter Network Between Patients With Erectile Dysfunction and Premature Ejaculation: A Graph Theory Analysis Study.Frontiers in neurology · 2022Article
- Article
- Cortico-cortical connectivity behind acoustic information transfer to mouse orbitofrontal cortex is sensitive to neuromodulation and displays local sensory gating: relevance in disorders with auditory hallucinations?Journal of psychiatry & neuroscience : JPN · 2021Article
- Posttraumatic stress symptom persistence across 24 years: association with brain structures.Brain imaging and behavior · 2020Article
- Altered heartbeat perception sensitivity associated with brain structural alterations in generalised anxiety disorder.General psychiatry · 2020Article
- Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood.Frontiers in aging neuroscience · 2018Article
- Inhibitory modulation of medial prefrontal cortical activation on lateral orbitofrontal cortex-amygdala information flow.The Journal of physiology · 2017Article
- Lateral Orbitofrontal Cortical Modulation on the Medial Prefrontal Cortex-Amygdala Pathway: Differential Regulation of Intra-Amygdala GABAA and GABAB Receptors.The international journal of neuropsychopharmacology · 2017Article
- "Weeding out" violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression.Aggression and violent behaviorArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The amygdala receives cortical inputs from the medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC) that are believed to affect emotional control and cue-outcome contingencies, respectively. Although mPFC impact on the amygdala has been studied, how the OFC modulates mPFC-amygdala information flow, specifically the infralimbic (IL) division of mPFC, is largely unknown. In this study, combined in vivo extracellular single-unit recordings and pharmacological manipulations were used in anesthetized rats to examine how OFC modulates amygdala neurons responsive to mPFC activation. Compared with basal condition, pharmacological (N-Methyl-D-aspartate) or electrical activation of the OFC exerted an inhibitory modulation of the mPFC-amygdala pathway, which was reversed with intra-amygdala blockade of GABAergic receptors with combined GABAA and GABAB antagonists (bicuculline and saclofen). Moreover, potentiation of the OFC-related pathways resulted in a loss of OFC control over the mPFC-amygdala pathway. These results show that the OFC potently inhibits mPFC drive of the amygdala in a GABA-dependent manner; but with extended OFC pathway activation this modulation is lost. Our results provide a circuit-level basis for this interaction at the level of the amygdala, which would be critical in understanding the normal and pathophysiological control of emotion and contingency associations regulating behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.