Evidence map›Paper›PMID 29253029›Full record

ArticlePloS one2017

Sleep-wake functions and quality of life in patients with subthalamic deep brain stimulation for Parkinson's disease.

Panagiotis Bargiotas, Lukas Eugster, Michael Oberholzer, Ines Debove, M Lenard Lachenmayer, Johannes Mathis, Claudio Pollo, W M Michael Schüpbach, Claudio L Bassetti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Observational
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Panagiotis BargiotasDepartment of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-6502-8942
Lukas EugsterDepartment of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
Michael OberholzerDepartment of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
Ines DeboveDepartment of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
M Lenard LachenmayerDepartment of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
Johannes MathisDepartment of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
Claudio PolloDepartment of Neurosurgery, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
W M Michael SchüpbachDepartment of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
Claudio L BassettiDepartment of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSleep-wake disturbances (SWD) are frequent in Parkinson's disease (PD). The effect of deep brain stimulation (DBS) on SWD is poorly known. In this study we examined the subjective and objective sleep-wake profile and the quality of life (QoL) of PD patients in the context of subthalamic DBS. PATIENTS AND

methodsWe retrospectively analyzed data from PD patients and candidates for DBS in the nucleus suthalamicus (STN). Pre-DBS, sleep-wake assessments included subjective and objective (polysomnography, vigilance tests and actigraphy) measures. Post-DBS, subjective measures were collected. QoL was assessed using the Parkinson's Disease Questionnaire (PDQ-39) and the RAND SF-36-item Health Survey (RAND SF-36).

resultsData from 74 PD patients (62% male, mean age 62.2 years, SD = 8.9) with a mean UPDRS-III (OFF) of 34.2 (SD = 14.8) and 11.8 (SD = 4.5) years under PD treatment were analyzed. Pre-DBS, daytime sleepiness, apathy, fatigue and depressive symptoms were present in 49%, 34%, 38% and 25% of patients respectively but not always as co-occurring symptoms. Sleep-wake disturbances were significantly correlated with QoL scores. One year after STN DBS, motor signs, QoL and sleepiness improved but apathy worsened. Changes in QoL were associated with changes in sleepiness and apathy but baseline sleep-wake functions were not predictive of STN DBS outcome.

conclusionIn PD patients presenting for STN DBS, subjective and objective sleep-wake disturbances are common and have a negative impact on QoL before and after neurosurgery. Given the current preliminary evidence, prospective observational studies assessing subjective and objective sleep-wake variables prior to and after DBS are needed.

Indexed as

Quality of LifeSleepActigraphyAgedCohort StudiesDeep Brain StimulationFemaleFollow-Up StudiesHealth SurveysHumansMaleMiddle AgedParkinson DiseasePolysomnographyRetrospective StudiesSleep Wake Disorders

Identifiers

PMID29253029
PMCPMC5734707
OpenAlexW2780791946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.