ArticlePloS one2017
Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Association of Uterine Tissue Innervation and Peripheral Nerve Density with Adenomyosis Related Pain. A Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- 5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis.EBioMedicine · 2026Article
- Clinical challenges and therapeutic strategies in women with endometriosis, deep infiltrating endometriosis, and/or adenomyosis undergoing assisted reproductive technologies: a narrative review.Frontiers in reproductive health · 2026Review
- TNS1/TAGLN-enriched endometrial stromal cells is associated with a persistent fibrotic microenvironment in intrauterine adhesion.Frontiers in cell and developmental biology · 2026Article
- Adenomyosis-Modern Techniques for Ultrasound and Histo-Pathological Diagnosis of the Endo-Myometrial Junction Zone Changes.Journal of clinical medicine · 2025Article
- Combined magnetic resonance imaging with serum CA125 for dysmenorrhea in adenomyosis.Scientific reports · 2025Article
- Phenotypic heterogeneity in adenomyosis: internal and external subtypes.Archives of gynecology and obstetrics · 2025Observational
- Differences in the proteomic profiles of the eutopic endometrium in patients with internal and external adenomyosis.PLOS global public health · 2025Article
- The Impact of Adenomyosis on Pregnancy.Biomedicines · 2024Review
- Type and Location of Adenomyosis in Women with Recurrent Pregnancy Loss: A Transvaginal Ultrasonographic Assessment.Reproductive sciences (Thousand Oaks, Calif.) · 2024Observational
- Comparative analysis of endometrial, vaginal, and gut microbiota in patients with and without adenomyosis.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Transforming growth factor beta-1 (TGF-β1) expression in patients with adenomyosis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- Critical appraisal and narrative review of the literature in IVF/ICSI patients with adenomyosis and endometriosis.Frontiers in reproductive health · 2024Article
- Endometrial Inflammation and Impaired Spontaneous Decidualization: Insights into the Pathogenesis of Adenomyosis.International journal of environmental research and public health · 2023Review
- In Search of an Imaging Classification of Adenomyosis: A Role for Elastography?Journal of clinical medicine · 2022Review
- Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies.Human reproduction update · 2022Review
- Classifying Adenomyosis: Progress and Challenges.International journal of environmental research and public health · 2021Review
- Clinicopathological characteristics and imaging findings to identify adenomyosis-related symptoms.Reproductive medicine and biology · 2021Article
- Origin and Pathogenic Mechanisms of Uterine Adenomyosis: What Is Known So Far.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Effects of localisation of uterine adenomyosis on outcome of in vitro fertilisation/intracytoplasmic sperm injection fresh and frozen-thawed embryo transfer cycles: a multicentre retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the phenotypic characterization of fibrotic process in adenomyosis occurring at the inner or the outer myometrium.
methodsEight cases of adenomyosis occurring at the inner myometrium (Subtype I) and 10 cases of adenomyosis occurring at the outer myometrium (Subtype II), and 10 normal counterparts were used in this study. A immunohistochemical study for smooth muscle cells (SMCs) was performed using cytoskeletal proteins, Type I and III collagen, TGF-β and its signaling molecules.
resultsAn increased expression of Type I collagen was observed in the extracellular matrix of adenomyotic foci. In normal uteri, immunostaining of SMC differentiation marker proteins (Desmin, Smoothelin, Myosin heavy chain (MHC)) were absent or only found in low numbers at the inner myometrium, while all of these marker proteins were clearly stained at the outer myometrium. In both types of adenomyotic foci, Desmin, Smoothelin, and MHC commonly showed a negative staining at the adjacent area to the glands. A significant staining of Non-muscle myosin IIB, TGF-β, and phosphorylated TGF-β type I receptors were found only at the SMCs of Subtype II adenomyosis. The Smad3/2 ratio of Subtype II adenomyosis was significantly higher than that of Subtype I.
conclusionsThe inner myometrium of normal uteri was composed of undifferentiated phenotypes of SMCs, while the outer myometrium was composed of terminally differentiated SMCs. Various fibrotic processes have been suggested in the development of uterine adenomyosis. Distinct expression patterns of fibrosis related proteins have been shown to be implicated with differences in the subtypes of adenomyosis.
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