ArticleThe Clinical journal of pain2018
Altered Spontaneous Brain Activity in Patients With Idiopathic Trigeminal Neuralgia: A Resting-state Functional MRI Study.
Article in The Clinical journal of pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Pooled it
- A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders.NeuroImage. Clinical · 2018Pooled it
- Compressing the lumbar nerve root changes the frequency-associated cerebral amplitude of fluctuations in patients with low back/leg pain.Scientific reports · 2019Trial
- Brain Regional Predictors of Surgical Response Are Dynamically Associated with Post-Surgical Pain Relief in Trigeminal Neuralgia.Brain sciences · 2026Article
- The hijacked insula: A stratified model of affective touch modulation in chronic pain.Journal of neuropsychology · 2026Review
- Resting-state local brain functional synchronization after a single trigger-zone stimulation: with versus without evoked pain in classical trigeminal neuralgia patients.The journal of headache and pain · 2026Article
- Individualized rs-fMRI reveals brain-circuit heterogeneity and predicts early recurrence in trigeminal neuralgia.Frontiers in psychiatry · 2026Article
- Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.Journal of pain research · 2026Review
- Evaluating Dental Pain in Diverse Conditions: Findings From Short-Form McGill Pain Questionnaire Study.International dental journal · 2025Article
- Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia.Scientific reports · 2025Article
- Graph theory-driven structural and functional connectivity analyses revealing regulatory mechanisms of brain network in patients with classic trigeminal neuralgia.Brain imaging and behavior · 2025Article
- The alteration of the sensorimotor network in trigeminal neuralgia after microvascular decompression surgery: a follow-up study using independent component analysis.Frontiers in physiology · 2025Article
- Multi-network dynamical structure of the human brain in the setting of chronic pain: a coordinate-based meta-analysis.Brain communications · 2025Article
- Trigeminal neuralgia.Nature reviews. Disease primers · 2024Review
- Functional alterations of the brain default mode network and somatosensory system in trigeminal neuralgia.Scientific reports · 2024Article
- Altered trends of local brain function in classical trigeminal neuralgia patients after a single trigger pain.BMC medical imaging · 2024Article
- Imaging the neural substrate of trigeminal neuralgia pain using deep learning.Frontiers in human neuroscience · 2023Article
- Alteration of brain network centrality in CTN patients after a single triggering pain.Frontiers in neuroscience · 2023Article
- A multimodal meta-analysis of gray matter alterations in trigeminal neuralgia.Frontiers in neurology · 2023Review
- Amplitude of low-frequency fluctuation after a single-trigger pain in patients with classical trigeminal neuralgia.The journal of headache and pain · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo identify the changes of local coherence and intrinsic brain activity in resting-state idiopathic trigeminal neuralgia (ITN) patients by using regional homogeneity (ReHo) and fractional aptitude of low-frequency fluctuation (fALFF) analysis.
methodsReHo and fALFF were analyzed in 23 ITN patients and 23 age-matched and sex-matched pain-free controls to detect the functional abnormality in the brains of ITN patients. Correlations between ReHo and fALFF were analyses. ITN pain intensity were also assessed in the ITN group.
resultsCompared with pain-free controls, ITN patients exhibited significantly abnormal ReHo and fALFF in several brain regions, including the cerebellum, cingulate cortex, temporal lobe, putamen, occipital lobe, limbic lobe, precuneus, insula, medial, and superior frontal gyrus compared with healthy controls. Correlation analysis showed that ReHo values of several altered brain areas positively correlated with visual analog scale values. But no correlation was found between fALFF and visual analog scale. DISCUSSION: Our results showed that ITN patients exhibited significantly abnormal spontaneous brain activity in several brain regions that are involved in pain modulation and perception. The present study reflects the maladaptive process of daily pain attacks and may enhance the understanding of how chronic pain affects local intrinsic brain activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.