Observational studyJournal of cardiovascular medicine (Hagerstown, Md.)2018
Vitamin D, parathyroid hormone and cardiovascular risk: the good, the bad and the ugly.
Observational study in Journal of cardiovascular medicine (Hagerstown, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Association Between Vitamin D and Microvascular Changes in Early Diabetic Retinopathy in Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Vitamin D: A Bridge between Kidney and Heart.Life (Basel, Switzerland) · 2024Review
- Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview.Life (Basel, Switzerland) · 2024Review
- Physiological Evidence and Therapeutic Outcomes of Vitamin D on Cardiovascular Diseases.Current cardiology reviews · 2024Review
- Vitamin D Levels in Patients with Overlap Syndrome, Is It Associated with Disease Severity?Journal of personalized medicine · 2022Article
- The Role of Vitamin DJournal of clinical medicine · 2022Article
- The potential effect of cardiac function on pulmonary hypertension, other risk factors, and its impact on survival in dialysis patients.International urology and nephrology · 2021Observational
- Monthly fluctuations in 25-hydroxy-vitamin D levels in day and rotating night shift hospital workers.Journal of endocrinological investigation · 2020Article
- Calcium supplements: Good for the bone, bad for the heart? A systematic updated appraisal.Atherosclerosis · 2020Article
- Review
- Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia.Oxidative medicine and cellular longevity · 2020Article
- We are What We Eat: Impact of Food from Short Supply Chain on Metabolic Syndrome.Journal of clinical medicine · 2019Article
- Gene-environment interactions and vitamin D effects on cardiovascular risk.BMC medicine · 2019Article
- Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults.BMC medicine · 2019Observational
- The Antioxidant Therapy: New Insights in the Treatment of Hypertension.Frontiers in physiology · 2018Review
- Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications.Oxidative medicine and cellular longevity · 2018Article
- Innovative Approaches to Active and Healthy Ageing: Campania Experience to Improve the Adoption of Innovative Good Practices.Translational medicine @ UniSaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
: 25-Hydroxyvitamin D insufficiency and increased cardiovascular risk (CVR) association is still debated. The vitamin D (VitD)-dependent parathyroid hormone (PTH) is considered as the possible actuator of VitD effects on CVR. To investigate the association of CVR, PTH and VitD, we carried out blood pressure measurements and blood samples and collected information on dietary habits, anamnestic, clinical and metabolic data of 451 participants in the Salerno area (Southern Italy) during the World Hypertension Day (17 May). CVR was calculated according to the Framingham CVR charts. The overall population mean age was 51.6 ± 0.7 years, and female sex was slightly prevalent (55%). VitD deficiency (<20 ng/ml) was most frequent (59.7%). In this population, VitD and CVR did not correlate. VitD and PTH inversely correlated (r = -0.265, P < 0.001) as expected. PTH was in direct correlation (r = 0.225, P < 0.001) with CVR. Elevated PTH (75 percentile; ≥49.5 pg/ml) levels identify a population with higher CVR (11.8 ± 0.5 vs. 8.5 ± 0.3, P < 0.001). In a multivariate analysis, both age and PTH correlate to CVR, but not VitD. In conclusion, VitD does not directly affect CVR in the overall population. Rather, increased PTH might be a better predictor of CVR.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.