Evidence map›Paper›PMID 29252164›Full record

ArticleJournal of psychiatry & neuroscience : JPN2018

Always on guard: emotion regulation in women with borderline personality disorder compared to nonpatient controls and patients with cluster-C personality disorder.

Linda van Zutphen, Nicolette Siep, Gitta A Jacob, Gregor Domes, Andreas Sprenger, Bastian Willenborg, Rainer Goebel, Arnoud Arntz

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Article in Journal of psychiatry & neuroscience : JPN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Emotion Dysregulation in Personality Disorders.Current psychiatry reports · 2023
    Review
  9. Borderline Personality Disorder: Updates in a Postpandemic World.Focus (American Psychiatric Publishing) · 2022
    Review
  10. Article
  11. An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2021
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linda van ZutphenFrom the Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands (van Zutphen, Siep, Arntz); the Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany (Jacob); the Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany (Domes); the Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany (Domes); the Department of Biological and Clinical Psychology, University of Trier, Trier, Germany (Domes); the Departments of Neurology and Psychology, University of Lübeck, Lübeck, Germany (Sprenger); the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Willenborg); the Department of Cognitive Neuroscience, Maastricht University, Maastricht, the Netherlands (Goebel); the Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands (Goebel); and the Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands (Arntz).
Nicolette SiepFrom the Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands (van Zutphen, Siep, Arntz); the Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany (Jacob); the Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany (Domes); the Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany (Domes); the Department of Biological and Clinical Psychology, University of Trier, Trier, Germany (Domes); the Departments of Neurology and Psychology, University of Lübeck, Lübeck, Germany (Sprenger); the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Willenborg); the Department of Cognitive Neuroscience, Maastricht University, Maastricht, the Netherlands (Goebel); the Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands (Goebel); and the Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands (Arntz).
Gitta A JacobFrom the Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands (van Zutphen, Siep, Arntz); the Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany (Jacob); the Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany (Domes); the Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany (Domes); the Department of Biological and Clinical Psychology, University of Trier, Trier, Germany (Domes); the Departments of Neurology and Psychology, University of Lübeck, Lübeck, Germany (Sprenger); the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Willenborg); the Department of Cognitive Neuroscience, Maastricht University, Maastricht, the Netherlands (Goebel); the Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands (Goebel); and the Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands (Arntz).
Gregor DomesFrom the Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands (van Zutphen, Siep, Arntz); the Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany (Jacob); the Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany (Domes); the Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany (Domes); the Department of Biological and Clinical Psychology, University of Trier, Trier, Germany (Domes); the Departments of Neurology and Psychology, University of Lübeck, Lübeck, Germany (Sprenger); the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Willenborg); the Department of Cognitive Neuroscience, Maastricht University, Maastricht, the Netherlands (Goebel); the Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands (Goebel); and the Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands (Arntz).
Andreas SprengerFrom the Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands (van Zutphen, Siep, Arntz); the Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany (Jacob); the Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany (Domes); the Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany (Domes); the Department of Biological and Clinical Psychology, University of Trier, Trier, Germany (Domes); the Departments of Neurology and Psychology, University of Lübeck, Lübeck, Germany (Sprenger); the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Willenborg); the Department of Cognitive Neuroscience, Maastricht University, Maastricht, the Netherlands (Goebel); the Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands (Goebel); and the Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands (Arntz).
Bastian WillenborgFrom the Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands (van Zutphen, Siep, Arntz); the Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany (Jacob); the Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany (Domes); the Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany (Domes); the Department of Biological and Clinical Psychology, University of Trier, Trier, Germany (Domes); the Departments of Neurology and Psychology, University of Lübeck, Lübeck, Germany (Sprenger); the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Willenborg); the Department of Cognitive Neuroscience, Maastricht University, Maastricht, the Netherlands (Goebel); the Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands (Goebel); and the Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands (Arntz).
Rainer GoebelFrom the Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands (van Zutphen, Siep, Arntz); the Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany (Jacob); the Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany (Domes); the Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany (Domes); the Department of Biological and Clinical Psychology, University of Trier, Trier, Germany (Domes); the Departments of Neurology and Psychology, University of Lübeck, Lübeck, Germany (Sprenger); the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Willenborg); the Department of Cognitive Neuroscience, Maastricht University, Maastricht, the Netherlands (Goebel); the Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands (Goebel); and the Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands (Arntz).
Arnoud ArntzFrom the Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands (van Zutphen, Siep, Arntz); the Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany (Jacob); the Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany (Domes); the Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany (Domes); the Department of Biological and Clinical Psychology, University of Trier, Trier, Germany (Domes); the Departments of Neurology and Psychology, University of Lübeck, Lübeck, Germany (Sprenger); the Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany (Willenborg); the Department of Cognitive Neuroscience, Maastricht University, Maastricht, the Netherlands (Goebel); the Department of Neuroimaging and Neuromodeling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands (Goebel); and the Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands (Arntz).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBorderline personality disorder (BPD) is characterized by emotion dysregulation; however, it is unclear whether this is restricted to negative emotional stimuli or to what degree this is specific to BPD. We investigated neural correlates of hypothesized increased emotional sensitivity and impaired emotion regulation in patients with BPD.

methodsDuring functional MRI (fMRI) scanning, patients with BPD, nonpatient controls and patients with cluster-C personality disorder completed an emotion regulation task, including negative, positive and erotic social pictures.

resultsWe included 55 patients with BPD, 42 nonpatient controls and 24 patients with cluster-C personality disorder in our analyses. Passive viewing of negative stimuli resulted in greater activity in the anterior insula, temporoparietal junction and dorsolateral prefrontal cortex in patients with BPD than in nonpatient controls. The increased activity in the anterior insula and temporoparietal junction was also present when patients with BPD viewed positive stimuli. During regulation of negative stimuli compared with passive viewing, nonpatient controls showed greater activity in the dorsal anterior cingulate cortex, dorsolateral prefrontal cortex, middle temporal gyrus and bilateral inferior parietal lobule. Patients with BPD did not show this increase in activity. LIMITATIONS: Findings cannot be generalized to men, and patients represented a heterogeneous group regarding comorbid diagnoses and medication.

conclusionWhen looking at emotional stimuli, patients with BPD showed a unique pattern of activity, suggesting an increase in brain activity involved in emotion generation. In the case of negative stimuli this is accompanied by increased activity in regulation areas. In contrast, increase of regulation processes seems absent when patients with BPD are explicitly instructed to regulate. Results of diagnosis specificity support a dimensional rather than a dichotomous differentiation between BPD and cluster-C personality disorder regarding emotional sensitivity and emotional regulation of social stimuli.

Indexed as

AdolescentAdultAgedBorderline Personality DisorderBrainCase-Control StudiesEmotionsFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMiddle AgedPersonality DisordersPhotic StimulationYoung Adult

Identifiers

PMID29252164
PMCPMC5747534

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