Evidence map›Paper›PMID 29252163›Full record

ArticleJournal of psychiatry & neuroscience : JPN2018

Cardiorespiratory concerns shape brain responses during automatic panic-related scene processing in patients with panic disorder.

Katharina Feldker, Carina Yvonne Heitmann, Paula Neumeister, Leonie Brinkmann, Maximillan Bruchmann, Pienie Zwitserlood, Thomas Straube

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Altered White Matter Network Topology in Panic Disorder.Journal of personalized medicine · 2023
    Article
  6. Panic disorder respiratory subtype: psychopathology and challenge tests - an update.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Katharina FeldkerFrom the Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany (Feldker, Heitmann, Neumeister, Brinkmann, Bruchmann, Straube); and the Institute for Psychology, University of Muenster, Muenster, Germany (Zwitserlood).
Carina Yvonne HeitmannFrom the Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany (Feldker, Heitmann, Neumeister, Brinkmann, Bruchmann, Straube); and the Institute for Psychology, University of Muenster, Muenster, Germany (Zwitserlood).
Paula NeumeisterFrom the Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany (Feldker, Heitmann, Neumeister, Brinkmann, Bruchmann, Straube); and the Institute for Psychology, University of Muenster, Muenster, Germany (Zwitserlood).
Leonie BrinkmannFrom the Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany (Feldker, Heitmann, Neumeister, Brinkmann, Bruchmann, Straube); and the Institute for Psychology, University of Muenster, Muenster, Germany (Zwitserlood).
Maximillan BruchmannFrom the Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany (Feldker, Heitmann, Neumeister, Brinkmann, Bruchmann, Straube); and the Institute for Psychology, University of Muenster, Muenster, Germany (Zwitserlood).
Pienie ZwitserloodFrom the Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany (Feldker, Heitmann, Neumeister, Brinkmann, Bruchmann, Straube); and the Institute for Psychology, University of Muenster, Muenster, Germany (Zwitserlood).
Thomas StraubeFrom the Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany (Feldker, Heitmann, Neumeister, Brinkmann, Bruchmann, Straube); and the Institute for Psychology, University of Muenster, Muenster, Germany (Zwitserlood).
University of Münster · DEAugenstern · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased automatic processing of threat-related stimuli has been proposed as a key element in panic disorder. Little is known about the neural basis of automatic processing, in particular to task-irrelevant, panic-related, ecologically valid stimuli, or about the association between brain activation and symptomatology in patients with panic disorder.

methodsThe present event-related functional MRI (fMRI) study compared brain responses to task-irrelevant, panic-related and neutral visual stimuli in medication-free patients with panic disorder and healthy controls. Panic-related and neutral scenes were presented while participants performed a spatially nonoverlapping bar orientation task. Correlation analyses investigated the association between brain responses and panic-related aspects of symptomatology, measured using the Anxiety Sensitivity Index (ASI).

resultsWe included 26 patients with panic disorder and 26 heatlhy controls in our analysis. Compared with controls, patients with panic disorder showed elevated activation in the amygdala, brainstem, thalamus, insula, anterior cingulate cortex and midcingulate cortex in response to panic-related versus neutral task-irrelevant stimuli. Furthermore, fear of cardiovascular symptoms (a subcomponent of the ASI) was associated with insula activation, whereas fear of respiratory symptoms was associated with brainstem hyperactivation in patients with panic disorder. LIMITATIONS: The additional implementation of measures of autonomic activation, such as pupil diameter, heart rate, or electrodermal activity, would have been informative during the fMRI scan as well as during the rating procedure.

conclusionResults reveal a neural network involved in the processing of panic-related distractor stimuli in patients with panic disorder and suggest an automatic weighting of panic-related information depending on the magnitude of cardiovascular and respiratory symptoms. Insula and brainstem activations show function-related associations with specific components of panic symptomatology.

Indexed as

AdolescentAdultBrainCase-Control StudiesFearFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMiddle AgedPanic DisorderPhotic StimulationYoung Adult

Identifiers

PMID29252163
PMCPMC5747532
OpenAlexW2780310839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.