ReviewBirth defects research2017
Convergent neurobiological predictors of emergent psychopathology during adolescence.
Review in Birth defects research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Parental Deprivation- and Threat-Based Factors Associated with Youth Emotion-Based Neurocircuitry and Externalizing Behavior: A Systematic Review.Research on child and adolescent psychopathology · 2024Pooled it
- Gray and white matter morphology in substance use disorders: a neuroimaging systematic review and meta-analysis.Translational psychiatry · 2021Pooled it
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Distinct Representations of Irrelevant Emotional Information in the Visual Network Are Associated With Psychopathology in Youth.Biological psychiatry global open science · 2026Article
- Perceived Racism, Brain Development, and Internalizing and Externalizing Symptoms: Findings From the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Abnormal connectivity in the fronto-striatal network in adolescent depression with psychotic symptoms.Child and adolescent psychiatry and mental health · 2026Article
- Prenatal Adversities and Risk of Persistent Youth Psychopathology and Altered Cortical Thinning.JAMA psychiatry · 2026Article
- Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk.BMC medicine · 2026Article
- Lifespan investigation of brain volumetric changes associated with substance use disorders.Research square · 2025Article
- Brain structural correlates of an impending initial major depressive episode.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Bridging the gap: improving correspondence between low-field and high-field magnetic resonance images in young people.Frontiers in neurology · 2024Article
- The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development.Scientific data · 2023Article
- Anxiety onset in adolescents: a machine-learning prediction.Molecular psychiatry · 2023Article
- Cross-Sectional Descriptive Pilot Study on the Risk of Psychotic Disorders among Adolescents.Children (Basel, Switzerland) · 2021Article
- The development of structural covariance networks during the transition from childhood to adolescence.Scientific reports · 2021Article
- Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression.Frontiers in psychiatry · 2021Review
- Associations between nucleus accumbens structural connectivity, brain function, and initiation of binge drinking.Addiction biology · 2020Article
- Identifying Early Risk Factors for Addiction Later in Life: A Review of Prospective Longitudinal Studies.Current addiction reports · 2020Article
- Brain structure, IQ, and psychopathology in young offspring of patients with schizophrenia or bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- The Neuroscience of Drug Reward and Addiction.Physiological reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The adolescent brain undergoes significant structural and functional development. Through the use of magnetic resonance imaging in adolescents, it has been demonstrated that the prefrontal cortex, pertinent for executive control, demonstrates protracted development compared to limbic structures, active during emotion and reward processing. This asynchronous development creates a sensitive window during adolescence, in which many psychopathological disorders (i.e., mental health and substance use) emerge. This review outlines longitudinal studies that use magnetic resonance imaging to identify neurobiological predictors of emergent psychopathology (depression, anxiety, and substance use), during adolescence. Studies identifying neurobiological markers that predict onset and escalation of these disorders, as well as those that predict successful treatment outcomes are explored. An emphasis is placed on frontolimbic brain structures, a convergent neurobiological target for both emergent mental health issues and emergent substance use. The literature reviewed herein suggests that reduced volume and cortical thickness in frontolimbic regions, as well as reduced functional activation (particularly during task involving reward or emotional stimuli) in these regions, may serve as a neurobiological predictors of emergent psychopathology in adolescence. This knowledge is crucial, as it may be used to develop neurobiologically targeted prevention and intervention strategies for youth who are at-risk for developing these psychopathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.