ReviewHippocampus2020
The role of replay and theta sequences in mediating hippocampal-prefrontal interactions for memory and cognition.
Review in Hippocampus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.Dialogues in clinical neuroscience · 2027Review
- Between planning and map building: Prioritizing replay when future goals are uncertain.Neuron · 2025Review
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
- Disruption of hippocampal-prefrontal neural dynamics and risky decision-making in a mouse model of Alzheimer's disease.Cell reports · 2025Article
- Prioritizing replay when future goals are unknown.bioRxiv : the preprint server for biology · 2025Article
- Article
- Exploring cortical excitability in children with cerebral palsy through lower limb robot training based on MI-BCI.Scientific reports · 2025Article
- Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Worry and rumination elicit similar neural representations: neuroimaging evidence for repetitive negative thinking.Cognitive, affective & behavioral neuroscience · 2025Article
- Validation of a rodent model of episodic memory replay.Learning & behavior · 2025Article
- Hippocampal place cell sequences are impaired in a rat model of Fragile X Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Neural mechanisms of spatial navigation in ASD and TD children: insights from EEG microstate and functional connectivity analysis.Frontiers in psychiatry · 2025Article
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- Sleep EEG signatures in mouse models of 15q11.2-13.1 duplication (Dup15q) syndrome.Journal of neurodevelopmental disorders · 2024Article
- Olfactory Epithelium Stimulation Using Rhythmic Nasal Air-Puffs Improves the Cognitive Performance of Individuals with Acute Sleep Deprivation.Brain sciences · 2024Article
- Article
- Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia-a replication approach.Translational psychiatry · 2024Article
- GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders.Frontiers in cellular neuroscience · 2024Review
- Hearing loss in juvenile rats leads to excessive play fighting and hyperactivity, mild cognitive deficits and altered neuronal activity in the prefrontal cortex.Current research in neurobiology · 2024Article
- Analysis of EEG features and study of automatic classification in first-episode and drug-naïve patients with major depressive disorder.BMC psychiatry · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Sequential activity is seen in the hippocampus during multiple network patterns, prominently as replay activity during both awake and sleep sharp-wave ripples (SWRs), and as theta sequences during active exploration. Although various mnemonic and cognitive functions have been ascribed to these hippocampal sequences, evidence for these proposed functions remains primarily phenomenological. Here, we briefly review current knowledge about replay events and theta sequences in spatial memory tasks. We reason that in order to gain a mechanistic and causal understanding of how these patterns influence memory and cognitive processing, it is important to consider how these sequences influence activity in other regions, and in particular, the prefrontal cortex, which is crucial for memory-guided behavior. For spatial memory tasks, we posit that hippocampal-prefrontal interactions mediated by replay and theta sequences play complementary and overlapping roles at different stages in learning, supporting memory encoding and retrieval, deliberative decision making, planning, and guiding future actions. This framework offers testable predictions for future physiology and closed-loop feedback inactivation experiments for specifically targeting hippocampal sequences as well as coordinated prefrontal activity in different network states, with the potential to reveal their causal roles in memory-guided behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.