Evidence map›Paper›PMID 29251733›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2018

Parabiosis reveals leukocyte dynamics in the kidney.

Jeremie M Lever, Zhengqin Yang, Ravindra Boddu, Oreoluwa O Adedoyin, Lingling Guo, Reny Joseph, Amie M Traylor, Anupam Agarwal, James F George

Open access · bronzeAbstract read
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Acute kidney injury results in long-term alterations of kidney lymphatics in mice.American journal of physiology. Renal physiology · 2024
    Article
  5. Kidney resident macrophages have distinct subsets and multifunctional roles.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
  6. Article
  7. Article
  8. Frontiers in immunology · 2023
    Article
  9. T-cell receptor αβImmunology and cell biology · 2023
    Article
  10. Frontiers in immunology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Selective depletion of a CD64-expressing phagocyte subset mediates protection against toxic kidney injury and failure.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Article
  20. UAB-UCSD O'Brien Center for Acute Kidney Injury Research.American journal of physiology. Renal physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jeremie M LeverDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-4182-1545
Zhengqin YangDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ravindra BodduDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Oreoluwa O AdedoyinDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Lingling GuoDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Reny JosephDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Amie M TraylorDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Anupam AgarwalDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
James F GeorgeNephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Mentored Experiences in Research, Instruction and Teaching (MERIT) Program - administrative supplementK12GM088010 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2024
$9.2M
Human Heme Oxygenase-1 Gene Regulation in Renal InjuryR01DK059600 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ANUPAM, GEORGE, JAMES F · 2002 to 2019
$4.5M
The role of heme oxygenase-1 in the Immune ResponseR01DK083390 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM, GEORGE, JAMES F · 2011 to 2014
$1.3M
Lymphangiogenesis in the pathogenesis of Acute Kidney InjuryI01BX004047 · VA · BIRMINGHAM VA MEDICAL CENTER · PI ANUPAM AGARWAL, TIMMY C LEE · 2018 to 2026
–
American Heart Association-American Stroke Association 17PRE33370121BLRD VA I01 BX004047NIAMS NIH HHS P30 AR048311NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK059600NIDDK NIH HHS R01 DK083390NIGMS NIH HHS K12 GM088010NIGMS NIH HHS T32 GM008361
6 · The paper itself

Abstract

The immune cellular compartment of the kidney is involved in organ development and homeostasis, as well as in many pathological conditions. Little is known about the mechanisms that drive intrarenal immune responses in the presence of renal tubular and interstitial cell death. However, it is known that tissue-resident leukocytes have the potential to have distinct roles compared with circulating cells. We used a parabiosis model in C57BL/6 CD45 congenic and green fluorescent protein transgenic mice to better understand the dynamics of immune cells in the kidney. We found F4/80

Indexed as

ParabiosisAnimalsChimerismKidneyLymphocytesMice, Inbred C57BLSpleen

Identifiers

PMID29251733
PMCPMC5839939
OpenAlexW2775877042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.