ArticleeLife2017
Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06435104 (Effects of Aromatherapy on Anxiety and Tumor Immunity of Early Breast Cancer Patients,a Pilot Study), which is not on this map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Aromatherapy on Anxiety and Tumor Immunity of Early Breast Cancer Patients,a Pilot Study
Who cites it
63 citing papers in PubMed, 98 citations in OpenAlex.
- POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system.Neuron · 2026Article
- Article
- Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.bioRxiv : the preprint server for biology · 2026Article
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cell type-specific barcoding reveals the single-neuron projectional architecture of the mouse midbrain dopaminergic system.bioRxiv : the preprint server for biology · 2026Article
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.bioRxiv : the preprint server for biology · 2025Article
- A midbrain-to-ventral-striatum dopaminergic pathway orchestrates odor-guided insect predation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions.Molecular psychiatry · 2025Article
- Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior.Nature communications · 2025Article
- Optimized workflow for behavior-coupled fiber photometry experiment: improved data navigation and accessibility.Frontiers in neuroscience · 2025Article
- Article
- Article
- Review
- Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024Article
- Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic.World journal of diabetes · 2024Article
- Synaptic plasticity and roles of orexin in distinct domains of the olfactory tubercle.Frontiers in neural circuits · 2024Article
- Optogenetics Neuromodulation of the Nose.Behavioural neurology · 2024Review
- Connectivity of the olfactory tubercle: inputs, outputs, and their plasticity.Frontiers in neural circuits · 2024Review
- Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain.Science China. Life sciences · 2024Article
- Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life.Frontiers in neural circuits · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
Odor-preferences are usually influenced by life experiences. However, the neural circuit mechanisms remain unclear. The medial olfactory tubercle (mOT) is involved in both reward and olfaction, whereas the ventral tegmental area (VTA) dopaminergic (DAergic) neurons are considered to be engaged in reward and motivation. Here, we found that the VTA (DAergic)-mOT pathway could be activated by different types of naturalistic rewards as well as odors in DAT-cre mice. Optogenetic activation of the VTA-mOT DAergic fibers was able to elicit preferences for space, location and neutral odor, while pharmacological blockade of the dopamine receptors in the mOT fully prevented the odor-preference formation. Furthermore, inactivation of the mOT-projecting VTA DAergic neurons eliminated the previously formed odor-preference and strongly affected the Go-no go learning efficiency. In summary, our results revealed that the VTA (DAergic)-mOT pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.