Evidence map›Paper›PMID 29251595›Full record

ArticleeLife2017

Natural variation in stochastic photoreceptor specification and color preference in

Caitlin Anderson, India Reiss, Cyrus Zhou, Annie Cho, Haziq Siddiqi, Benjamin Mormann, Cameron M Avelis, Peter Deford, Alan Bergland, Elijah Roberts and 3 more

Abstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  8. Transcriptional priming and chromatin regulation during stochastic cell fate specification.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Insect opsins and evo-devo: what have we learned in 25 years?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caitlin AndersonDepartment of Biology, Johns Hopkins University, Baltimore, United States.ORCID http://orcid.org/0000-0003-2260-6209
India ReissDepartment of Biology, Johns Hopkins University, Baltimore, United States.
Cyrus Zhou *Department of Biology, Johns Hopkins University, Baltimore, United States.
Annie Cho *Department of Biology, Johns Hopkins University, Baltimore, United States.
Haziq Siddiqi *Department of Biology, Johns Hopkins University, Baltimore, United States.
Benjamin MormannCenter for Developmental Genetics, Department of Biology, New York University, New York, United States.
Cameron M AvelisDepartment of Biophysics, Johns Hopkins University, Baltimore, United States.
Peter DefordDepartment of Biology, Johns Hopkins University, Baltimore, United States.
Alan BerglandDepartment of Biology, University of Virginia, Charlottesville, United States.ORCID http://orcid.org/0000-0001-7145-7575
Elijah RobertsDepartment of Biophysics, Johns Hopkins University, Baltimore, United States.
James TaylorDepartment of Biology, Johns Hopkins University, Baltimore, United States.ORCID http://orcid.org/0000-0001-5079-840X
Daniel VasiliauskasParis-Saclay Institute of Neuroscience, Université Paris Sud, Centre National de la Recherche Scientifque, Université Paris-Saclay, Gif-sur-Yvette, France.
Robert J JohnstonDepartment of Biology, Johns Hopkins University, Baltimore, United States.ORCID http://orcid.org/0000-0002-5775-6218

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
PROGRAM IN MOLECULAR BIOPHYSICST32GM008403 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BARRICK, DOUGLAS E. · 1990 to 2019
$13.5M
Mechanisms controlling stochastic gene expression during eye developmentR01EY025598 · NEI · JOHNS HOPKINS UNIVERSITY · PI Robert John Johnston · 2015 to 2026
$4.9M
NEI NIH HHS R01 EY025598NIGMS NIH HHS T32 GM007231NIGMS NIH HHS T32 GM008403
6 · The paper itself

Abstract

Each individual perceives the world in a unique way, but little is known about the genetic basis of variation in sensory perception. In the fly eye, the random mosaic of color-detecting R7 photoreceptor subtypes is determined by stochastic on/off expression of the transcription factor Spineless (Ss). In a genome-wide association study, we identified a naturally occurring insertion in a regulatory DNA element in

Indexed as

Behavior, AnimalColorVisual PerceptionAnimalsDNA-Binding ProteinsDrosophilaDrosophila ProteinsGene Expression RegulationMutagenesis, InsertionalPhotoreceptor CellsProtein BindingReceptors, Aryl HydrocarbonRegulatory Sequences, Nucleic AcidTranscription FactorsDNA-Binding ProteinsDrosophila ProteinsKlu protein, DrosophilaReceptors, Aryl Hydrocarbonss protein, DrosophilaTranscription Factorschromosomescolor preferencedevelopmental biologyD. melanogastergenesKlumpfussnatural variationphotoreceptorSpinelessstem cellsstochastic cell fate specification

Identifiers

PMID29251595
PMCPMC5745083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.