Evidence map›Paper›PMID 29251114›Full record

ArticleCell transplantation2017

S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis.

Jia-Ning Syu, Mei-Due Yang, Shu-Yao Tsai, En-Pei Isabel Chiang, Shao-Chih Chiu, Che-Yi Chao, Raymond L Rodriguez, Feng-Yao Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Reckoning γ-Glutamyl-S-allylcysteine as a potential main protease (mDrug development and industrial pharmacy · 2021
    Article
  12. Protective Effect of S-Allyl Cysteine Against Neonatal Asthmatic Rats.Dose-response : a publication of International Hormesis Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jia-Ning Syu1 Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan, Republic of China.
Mei-Due Yang2 Department of Clinical Nutrition, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China.
Shu-Yao Tsai5 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, Republic of China.
En-Pei Isabel Chiang6 Department of Food Science and Biotechnology, NCHU-UCD Plant and Food Biotechnology Center and Agricultural Biotechnology Center (ABC), National Chung Hsing University, Taichung, Taiwan, Republic of China.
Shao-Chih Chiu7 Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China.
Che-Yi Chao5 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, Republic of China.
Raymond L Rodriguez10 Department of Molecular and Cellular Biology, University of California, Davis, CA, USA.
Feng-Yao Tang1 Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan, Republic of China.
China Medical University Hospital · TWChina Medical University · TWAsia University · TWNational Chung Hsing University · TWUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD. However, the protective effects of SAC on the ischemic injury are not yet clear. In this study, we examined whether SAC could improve blood flow recovery in ischemic tissues through EPC-mediated neovasculogenesis. The results demonstrate that SAC significantly enhances the neovasculogenesis of EPCs in vitro. The molecular mechanisms for SAC enhancement of neovasculogenesis include the activation of Akt/endothelial nitric oxide synthase signaling cascades. SAC increased the expression of c-kit, β-catenin, cyclin D1, and Cyclin-dependent kinase 4 (CDK4) proteins in EPCs. Daily intake of SAC at dosages of 0.2 and 2 mg/kg body weight significantly enhanced c-kit protein levels in vivo. We conclude that dietary consumption of SAC improves blood flow recovery and prevents ischemic injury by inducing neovasculogenesis in experimental models.

Indexed as

AnimalsCell ProliferationCysteineEndothelial Progenitor CellsFemaleHumansMiceNeovascularization, PhysiologicSignal TransductionCysteineS-allylcysteineAktc-kithuman endothelial progenitor cellsneovascularizationS-allylcysteine

Identifiers

PMID29251114
PMCPMC5753981
OpenAlexW2777292851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.