Evidence map›Paper›PMID 29251108›Full record

ArticleCell transplantation2017

Sertoli Cells Loaded with Doxorubicin in Lipid Micelles Reduced Tumor Burden and Dox-Induced Toxicity.

Mahasweta Das, Mark Howell, Elspeth A Foran, Rohit Iyre, Shyam S Mohapatra, Subhra Mohapatra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Nanocarrier-based immunotherapy for viral diseases.International journal of pharmaceutics: X · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahasweta Das1 Center for Research and Education in Nanobioengineering, University of South Florida College of Medicine, Tampa, FL, USA.
Mark Howell3 Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, FL, USA.
Elspeth A Foran3 Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, FL, USA.
Rohit Iyre2 Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA.
Shyam S Mohapatra1 Center for Research and Education in Nanobioengineering, University of South Florida College of Medicine, Tampa, FL, USA.
Subhra Mohapatra1 Center for Research and Education in Nanobioengineering, University of South Florida College of Medicine, Tampa, FL, USA.

Funding

An Integrated Nano-Cell Delivery Platform of Theranostics for Lung CancersR01CA152005 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI MOHAPATRA, SHYAM S, MOHAPATRA, SUBHRA · 2010 to 2014
$1.4M
BLRD VA IK6 BX004212NCI NIH HHS R01 CA152005
6 · The paper itself

Abstract

The toxic side effects of doxorubicin (Dox) limit its long-term use as a lung cancer chemotherapeutic. Additionally, drug delivery to the deep lung is challenging. To address these challenges, isolated rat Sertoli cells (SCs) were preloaded with Dox conjugated to lipid micelle nanoparticles (SC-DLMNs) and delivered to mouse lungs. These immunocompetent cells, when injected intravenously, travel to the lung, deliver the payload, and get cleared by the system quickly without causing any adverse reaction. We observed that SC-DLMNs effectively treated Lewis lung carcinoma 1-induced lung tumors in mice and the drug efficacy was comparable to SC-Dox treatment. Mice treated with SC-DLMNs also showed significantly less toxicity compared to those treated with SC-Dox. The encapsulation of Dox in lipid micelle nanoparticles reduced the toxicity of Dox and the SC-based delivery method ensured drug delivery to the deep lung without evoking any immune response. Taken together, these results provide a novel SC-based nanoparticle drug delivery method for improved therapeutic outcome of cardiotoxic antilung cancer drugs.

Indexed as

AnimalsDoxorubicinHumansLipidsMaleMiceMicellesMicroscopy, ConfocalNanoparticlesRats, Sprague-DawleySertoli CellsTumor BurdenDoxorubicinLipidsMicellesdoxorubicin (Dox)drug toxicitylipid micelle nanoparticleslung cancerSertoli cell

Identifiers

PMID29251108
PMCPMC5753976

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.