ReviewCritical reviews in biochemistry and molecular biology2018
The impact of non-genetic heterogeneity on cancer cell death.
Review in Critical reviews in biochemistry and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Breaking the heterogeneity barrier: a robust prognostic signature for survival stratification and immune profiling in triple-negative breast cancer.Frontiers in immunology · 2025Article
- Morphological and Immunocytochemical Characterization of Paclitaxel-Induced Microcells in Sk-Mel-28 Melanoma Cells.Biomedicines · 2024Article
- TOR regulates variability of protein synthesis rates.The EMBO journal · 2024Article
- Predictability: A new distinguishing feature of cancer?PloS one · 2024Article
- Modeling Cellular Signaling Variability Based on Single-Cell Data: The TGFβ-SMAD Signaling Pathway.Methods in molecular biology (Clifton, N.J.) · 2023Review
- A lineage tree-based hidden Markov model quantifies cellular heterogeneity and plasticity.Communications biology · 2022Article
- Article
- Cellular Environment and Phenotypic Heterogeneity: How Data-Driven Modeling Finds the Smoking Gun.International journal of molecular sciences · 2022Article
- Emergence of hybrid states of stem-like cancer cells correlates with poor prognosis in oral cancer.iScience · 2022Article
- Identifying cell-to-cell variability in internalization using flow cytometry.Journal of the Royal Society, Interface · 2022Article
- Synthesis and preliminary evaluation of octreotate conjugates of bioactive synthetic amatoxins for targeting somatostatin receptor (sstr2) expressing cells.RSC chemical biology · 2022Article
- Review
- Precision Oncology Beyond Genomics: The Future Is Here-It Is Just Not Evenly Distributed.Cells · 2021Review
- Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer.eLife · 2021Article
- Kinetic Heterogeneity of Cancer Cell Fractional Killing.Cell reports · 2020Article
- The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy.Molecular biology of the cell · 2020Article
- An Improved ATP FRET Sensor For Yeast Shows Heterogeneity During Nutrient Transitions.ACS sensors · 2020Article
- A systems approach to clinical oncology uses deep phenotyping to deliver personalized care.Nature reviews. Clinical oncology · 2020Review
- Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology.Frontiers in bioengineering and biotechnology · 2020Article
- Intracellular CaFrontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The goal of cancer chemotherapy is to induce homogeneous cell death within the population of targeted cancer cells. However, no two cells are exactly alike at the molecular level, and sensitivity to drug-induced cell death, therefore, varies within a population. Genetic alterations can contribute to this variability and lead to selection for drug resistant clones. However, there is a growing appreciation for the role of non-genetic variation in producing drug-tolerant cellular states that exhibit reduced sensitivity to cell death for extended periods of time, from hours to weeks. These cellular states may result from individual variation in epigenetics, gene expression, metabolism, and other processes that impact drug mechanism of action or the execution of cell death. Such population-level non-genetic heterogeneity may contribute to treatment failure and provide a cellular "substrate" for the emergence of genetic alterations that confer frank drug resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.