ArticleHuman brain mapping2018
Physical neglect during childhood alters white matter connectivity in healthy young males.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder.Behavioural neurology · 2021Pooled it
- Early Parenting Intervention and Adverse Family Environments Affect Neural Function in Middle Childhood.Biological psychiatry · 2019Trial
- Brain controllability mediates the effects of early life adversity on adolescent behavior and cognition moderated by genetic risks.Research square · 2026Article
- Do white matter microstructural alterations associated with childhood maltreatment explain psychopathology in early adulthood?-a longitudinal neuroimaging study.European child & adolescent psychiatry · 2026Article
- Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based multivariate pattern analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Functional connectivity of youth in family-like residential care in Japan: Impact of reactive attachment disorder and disinhibited social engagement disorder symptoms.Neuroimage. Reports · 2026Article
- Childhood Adversity Is Associated With Longitudinal White Matter Changes After Adulthood Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- White matter microstructure abnormalities in children experiencing neglect without other forms of maltreatment.Scientific reports · 2025Article
- Characteristic parameter analysis of magnetic resonance diffusion tensor imaging in children with autism spectrum disorder: a retrospective study.BMC pediatrics · 2025Article
- Brain White Matter Alterations in Young Adults with Childhood Emotional Neglect Experience.Behavioral sciences (Basel, Switzerland) · 2025Article
- Whole-brain white matter variation across childhood environments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Increased Brain Age Among Psychiatrically Healthy Adults Exposed to Childhood Trauma.Brain and behavior · 2025Article
- BDNF Gene Polymorphism and Antidepressant Response in Han Chinese Patients with First-Episode Late-Life Depression.Alpha psychiatry · 2025Article
- The relationship between childhood trauma and social anxiety in college students: the mediating role of evaluation fear.BMC psychiatry · 2025Article
- Association between disturbance of self-organization and irritable bowel syndrome in Japanese population using the international trauma questionnaire.Scientific reports · 2024Article
- Making Connections: Neurodevelopmental Changes in Brain Connectivity After Adverse Experiences in Early Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Association of Blood Metabolomics Biomarkers with Brain Metabolites and Patient-Reported Outcomes as a New Approach in Individualized Diagnosis of Schizophrenia.International journal of molecular sciences · 2024Article
- Alterations in the white matter structure of major depressive disorder patients and their link to childhood trauma.Frontiers in psychiatry · 2024Article
- Uncinate fasciculus microstructural organisation and emotion recognition in schizophrenia: controlling for hit rate bias.Frontiers in behavioral neuroscience · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood adversity (CA) leads to greater vulnerability for psychopathology by causing structural as well as functional brain abnormalities. Recent findings on gray matter effects point towards the importance of identifying CA outcome as a function of different CA types, varying in the dimensions of threat and deprivation. Using diffusion tensor imaging, we investigate whether different forms of CA impact differently on white matter connectivity in a healthy cohort not confounded by other aspects of disease.
methodsIn 120 healthy young males, we assessed different forms of maltreatment during childhood with the Childhood Trauma Questionnaire (CTQ). Fractional anisotropy (FA) and mean diffusivity (MD) images were generated and projected onto a white matter skeleton using tract-based spatial statistics. Correlational analysis between FA, MD, and CTQ subscores was then performed using voxelwise statistics.
resultsOf all CTQ-subscores, only physical neglect (PN) predicted a decrease of FA but not MD in the bilateral anterior thalamic radiation around the middle frontal gyrus and the right inferior fronto-occipital fasciculus, the inferior longitudinal fasciculus, the cingulum and precuneus. Reduced FA in the posterior cingulum was related to the effects of PN during childhood on anxiety levels at trend level.
conclusionsPN may have severe consequences and should be considered equally important to more active forms of abuse. FA changes, particularly in the cingulum, actually appear to a functional consequence and are linked to trait anxiety, a personality dimension that is suggested to be a transdiagnostic risk factor of affective disorders. Potentially this reveals a mechanistic chain that forms one pathyway from CA to disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.