Evidence map›Paper›PMID 29250817›Full record

ArticleStatistics in medicine2018

A Bayesian semiparametric latent variable approach to causal mediation.

Chanmin Kim, Michael Daniels, Yisheng Li, Kathrin Milbury, Lorenzo Cohen

Abstract read
In one paragraph

Article in Statistics in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chanmin KimDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.ORCID 0000-0002-2588-6704
Michael DanielsDepartment of Statistics, University of Florida, Gainesville, FL 32611, USA.
Yisheng LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-9847-8544
Kathrin MilburyDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Lorenzo CohenDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Biobehavioral Effects of Emotional Expression in CancerR01CA090966 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI COHEN, LORENZO · 2002 to 2006
$2.5M
BAYESIAN APPROACHES FOR MISSINGNESS AND CAUSALITY IN CANCER AND BEHAVIOR STUDIESR01CA183854 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI DANIELS, MICHAEL J · 2014 to 2019
$1.7M
Non-Parametric Bayesian Methods for Causal InferenceR01GM112327 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ROY, JASON A · 2014 to 2017
$1.4M
Couple-Based Mind-Body Program for Lung Cancer Patients and their PartnersK01AT007559 · NCCIH · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILBURY, KATHRIN · 2013 to 2017
$652k
NCCIH NIH HHS K01 AT007559NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA090966NCI NIH HHS R01 CA183854NIGMS NIH HHS R01 GM112327
6 · The paper itself

Abstract

In assessing causal mediation effects in randomized studies, a challenge is that the direct and indirect effects can vary across participants due to different measured and unmeasured characteristics. In that case, the population effect estimated from standard approaches implicitly averages over and does not estimate the heterogeneous direct and indirect effects. We propose a Bayesian semiparametric method to estimate heterogeneous direct and indirect effects via clusters, where the clusters are formed by both individual covariate profiles and individual effects due to unmeasured characteristics. These cluster-specific direct and indirect effects can be estimated through a set of regression models where specific coefficients are clustered by a stick-breaking prior. To let clustering be appropriately informed by individual direct and indirect effects, we specify a data-dependent prior. We conduct simulation studies to assess performance of the proposed method compared to other methods. We use this approach to estimate heterogeneous causal direct and indirect effects of an expressive writing intervention for patients with renal cell carcinoma.

Indexed as

Bayes TheoremCluster AnalysisRegression AnalysisCausalityComputer SimulationEffect Modifier, EpidemiologicHumansTreatment OutcomeBayesian nonparametricscausal inferencecluster-specific effectseffect modificationsequential ignorability

Identifiers

PMID29250817
PMCPMC5837944

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.