Evidence map›Paper›PMID 29250738›Full record

ArticlePsychopharmacology2018

Effects of muscarinic M

Kevin Stoll, Rachel Hart, Craig W Lindsley, Morgane Thomsen

Abstract read
In one paragraph

Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. [Pharmacological reports : PR · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Acetylcholine Muscarinic MBiological psychiatry · 2020
    Article
  12. Effects of muscarinic MNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kevin StollAlcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA.
Rachel HartAlcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA.
Craig W LindsleyVanderbilt Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Morgane ThomsenAlcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA. mthomsen@mclean.harvard.edu.ORCID 0000-0002-7250-6006

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The Vanderbilt Specialized Chemistry Center for Accelerated Probe DevelopmentU54MH084659 · NIMH · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2008 to 2013
$24.1M
Selective Muscarinic Receptor Ligands as Targets for Cocaine Addiction MedicationR00DA027825 · NIDA · MCLEAN HOSPITAL · PI THOMSEN, MORGANE HERMANN · 2012 to 2014
$710k
Selective Muscarinic Receptor Ligands as Targets for Cocaine Addiction MedicationK99DA027825 · NIDA · MCLEAN HOSPITAL · PI THOMSEN, MORGANE HERMANN · 2010 to 2011
$247k
NCATS NIH HHS UL1 TR001102NIDA NIH HHS K99 DA027825NIDA NIH HHS R00 DA027825NIMH NIH HHS U54 MH084659NIMH NIH HHS U54MH084659
6 · The paper itself

Abstract

rationaleStimulating muscarinic M

objectivesWe tested whether stimulating M

methodsExperimentally naïve C57BL/6J mice were allowed to acquire self-administration of intravenous cocaine (1 mg/kg/infusion) under a fixed-ratio 1 schedule of reinforcement. Then, saline was substituted for cocaine until responding extinguished to ≤30% of cocaine-reinforced responding. Immediately after each extinction session, mice received saline, the M

resultsStimulating M

conclusionsThese findings show that M

Indexed as

AnimalsCocaineCocaine-Related DisordersDrug-Seeking BehaviorExtinction, PsychologicalMaleMiceMice, Inbred C57BLMuscarinic AgonistsPyridinesReceptor, Muscarinic M1Receptor, Muscarinic M4Reinforcement, PsychologyThiadiazolesThiophenes3-amino-N-(4-methoxybenzyl)-4,6-dimethylthieno(2,3-b)pyridine-2-carboxamideCocaineMuscarinic AgonistsPyridinesReceptor, Muscarinic M1Receptor, Muscarinic M4ThiadiazolesThiophenesxanomelineAbuseAddictionC57BL/6CholinergicExtinctionMousePreclinicalPsychostimulantRelapse

Identifiers

PMID29250738
PMCPMC6472894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.