Evidence map›Paper›PMID 29250607›Full record

ArticleInfectious Disease Modelling2017

Fitting dynamic models to epidemic outbreaks with quantified uncertainty: A Primer for parameter uncertainty, identifiability, and forecasts.

Gerardo Chowell

Abstract read
In one paragraph

Article in Infectious Disease Modelling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Key questions for modelling COVID-19 exit strategies.Proceedings. Biological sciences · 2020
    Pooled it
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  13. Immunogenic cell death unlocks the potential for combined radiation and immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2025
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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Gerardo ChowellDivision of Epidemiology & Biostatistics, School of Public Health, Georgia State University, Atlanta, GA, USA.

Funding

Modeling Anthropogenic Effects in the Spread of Infectious DiseasesR01GM100471 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PERRINGS, CHARLES · 2011 to 2014
$1.5M
NIGMS NIH HHS R01 GM100471
6 · The paper itself

Abstract

Mathematical models provide a quantitative framework with which scientists can assess hypotheses on the potential underlying mechanisms that explain patterns in the observed data at different spatial and temporal scales, generate estimates of key kinetic parameters, assess the impact of interventions, optimize the impact of control strategies, and generate forecasts. We review and illustrate a simple data assimilation framework for calibrating mathematical models based on ordinary differential equation models to time series data describing the temporal progression of case counts relating to population growth or infectious disease transmission dynamics. In contrast to Bayesian estimation approaches that always raise the question of how to set priors for the parameters, this frequentist approach relies on modeling the error structure in the data. We discuss issues related to parameter identifiability, uncertainty quantification and propagation as well as model performance and forecasts along examples based on phenomenological and mechanistic models parameterized using simulated and real datasets.

Indexed as

bootstrapforecastsmodel performanceParameter estimationparameter identifiabilityuncertainty propagationuncertainty quantification

Identifiers

PMID29250607
PMCPMC5726591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.