ArticleScience advances2017
Reactivity of prehydrated electrons toward nucleobases and nucleotides in aqueous solution.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 90 citations in OpenAlex.
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- The Anionic States of Ubiquinone Characterized by Second-Order Approximate Coupled-Cluster Theory.Journal of computational chemistry · 2026Article
- The Influence of Water Molecules on the π* Shape Resonances of the Thymine Anion.The journal of physical chemistry. A · 2025Article
- Low-Energy Photoelectron Spectroscopy and Scattering from Aqueous Solutions and the Role of Solute Surface Activity.Journal of the American Chemical Society · 2025Article
- Electron interaction with laser-desorbed thymidine and guanine in the gas phase.The European physical journal. D, Atomic, molecular, and optical physics · 2025Article
- Significant role of secondary electrons in the formation of a multi-body chemical species spur produced by water radiolysis.Scientific reports · 2024Article
- Enzyme-activatable charge transfer in gold nanoclusters.Chemical science · 2024Article
- Unraveling the Complexity of DNA Radiation Damage Using DNA Nanotechnology.Accounts of chemical research · 2024Article
- First-principles simulation of an ejected electron produced by monochromatic deposition energy to water at the femtosecond order.RSC advances · 2023Article
- Dissociative Electron Attachment to 5-Iodo-4-thio-2'-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells.The journal of physical chemistry letters · 2023Article
- Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Pathways of the Dissociative Electron Attachment Observed in 5- and 6-Azidomethyluracil Nucleosides: Nitrogen (NThe journal of physical chemistry. B · 2023Article
- Low-Energy Shape Resonances of a Nucleobase in Water.Journal of the American Chemical Society · 2023Article
- Guanosine Dianions Hydrated by One to Four Water Molecules.The journal of physical chemistry letters · 2022Article
- Electron Holes in G-Quadruplexes: The Role of Adenine Ending Groups.International journal of molecular sciences · 2021Article
- Quasi-Free Electron-Mediated Radiation Sensitization by C5-Halopyrimidines.The journal of physical chemistry. A · 2021Article
- Low-Energy Electron Damage to Condensed-Phase DNA and Its Constituents.International journal of molecular sciences · 2021Review
- In situ monitoring of the influence of water on DNA radiation damage by near-ambient pressure X-ray photoelectron spectroscopy.Communications chemistry · 2021Article
- Ring-Selective Fragmentation in the Tirapazamine Molecule upon Low-Energy Electron Attachment.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
DNA damage induced via dissociative attachment by low-energy electrons (0 to 20 eV) is well studied in both gas and condensed phases. However, the reactivity of ultrashort-lived prehydrated electrons ([Formula: see text]) with DNA components in a biologically relevant environment has not been fully explored to date. The electron transfer processes of [Formula: see text] to the DNA nucleobases G, A, C, and T and to nucleosides/nucleotides were investigated by using 7-ps electron pulse radiolysis coupled with pump-probe transient absorption spectroscopy in aqueous solutions. In contrast to previous results, obtained by using femtosecond laser pump-probe spectroscopy, we show that G and A cannot scavenge [Formula: see text] at concentrations of ≤50 mM. Observation of a substantial decrease of the initial yield of hydrated electrons ([Formula: see text]) and formation of nucleobase/nucleotide anion radicals at increasing nucleobase/nucleotide concentrations present direct evidence for the earliest step in reductive DNA damage by ionizing radiation. Our results show that [Formula: see text] is more reactive with pyrimidine than purine nucleobases/nucleotides with a reactivity order of T > C > A > G. In addition, analyses of transient signals show that the signal due to formation of the resulting anion radical directly correlates with the loss of the initial [Formula: see text] signal. Therefore, our results do not agree with the previously proposed dissociation of transient negative ions in nucleobase/nucleotide solutions within the timescale of these experiments. Moreover, in a molecularly crowded medium (for example, in the presence of 6 M phosphate), the scavenging efficiency of [Formula: see text] by G is significantly enhanced. This finding implies that reductive DNA damage by ionizing radiation depends on the microenvironment around [Formula: see text].
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