ArticleACS biomaterials science & engineering2017
Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials.
Article in ACS biomaterials science & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers.
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The trial behind it
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Who cites it
177 citing papers in PubMed.
- Water-Activated Phospholipid Phase-Separation Gel as an Immunomodulatory Anti-Adhesion Barrier for Postoperative Adhesion Prevention.Advanced healthcare materials · 2026Article
- Injectable hydrogels for bone regeneration: from materials design to clinical translation.RSC advances · 2026Review
- A multifunctional hydrogel dressing for wound healing and in vitro cytotoxicity against breast cancer cells: association with GRP78 expression.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Compartmentalized Dual-Drug Injectable Hydrogel for Anti-Inflammatory Activity and Osteoarthritic Cartilage Repair.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Tunable Fabrication of 2D-Layered Magnesium Nanosilicates With Hemostatic Properties.Small science · 2026Article
- Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theranostics.Pharmaceutics · 2026Review
- Topical Tinospora cordifolia BSA Hydrogel Formulation Attenuates UVB-Induced Skin Inflammation in Golden Hamsters.Chemistry & biodiversity · 2026Article
- ROS-responsive injectable hydrogel enables controlled release of human adipose tissue-derived extracellular vesicles for multifaceted osteoarthritis therapy.Journal of nanobiotechnology · 2026Article
- Sustainable Cellulose-Based Gels: Synthesis, Chemical Modification, and Biomedical Application.Gels (Basel, Switzerland) · 2026Review
- Support-Enabled 3D Printing of Complex Anisotropic Hydrogel Structures Using Cellulose-Based Inks: Pathways Toward Biomimetic Human Aorta Models.ACS biomaterials science & engineering · 2026Article
- Injectable and viscoelastic click alginate hydrogels for spatio-temporal T cell administration in vivo.Materials today. Bio · 2026Article
- Injectable Silk Fibroin-Puerarin Hydrogels with Tunable Supramolecular Organization as a Potential Platform for Tissue Engineering.ACS omega · 2026Article
- Ribbon-shaped microgels as bioinks for 3D bioprinting of anisotropic tissue structures.Bioactive materials · 2026Article
- Adaptive PEG Bis-dendron Hydrogels with Tunable Mechanics and Bioactivity.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- Evaluation of the Potential of a Fast-Curing Polymer Bioadhesive Hydrogel for Corneal Defect Repair.Gels (Basel, Switzerland) · 2026Article
- Photoreductive Degradation of Fe(III)-Catechol Crosslinked Hydrogels under Visible Light.Chemistry, an Asian journal · 2026Article
- Intra-articular dual-targeted hydrogel co-delivering diacerein nanoparticles and ketorolac for modulating neuroimmune interplay and cartilage degeneration in osteoarthritis.Drug delivery and translational research · 2026Article
- Simultaneous Cross-Linking and Nanoparticle Anchoring by Dialdehyde Cellulose in Injectable Composite Chitosan/Polypyrrole Hydrogels.ACS applied bio materials · 2026Article
- Cell-Laden Supramolecular and Covalent Polymer Hydrogels for High-Shear Delivery: A Design of Experiments Approach.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- Article
117 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Injectable hydrogels have gained popularity as a vehicle for the delivery of cells, growth factors, and other molecules to localize and improve their retention at the injection site, as well as for the mechanical bulking of tissues. However, there are many factors, such as viscosity, storage and loss moduli, and injection force, to consider when evaluating hydrogels for such applications. There are now numerous tools that can be used to quantitatively assess these factors, including for shear-thinning hydrogels because their properties change under mechanical load. Here, we describe relevant rheological tests and ways to measure injection force using a force sensor or a mechanical testing machine toward the evaluation of injectable hydrogels. Injectable, shear-thinning hydrogels can be used in a variety of clinical applications, and as an example we focus on methods for injection into the heart, where an understanding of injection properties and mechanical forces is imperative for consistent hydrogel delivery and retention. We discuss methods for delivery of hydrogels to mouse, rat, and pig hearts in models of myocardial infarction, and compare methods of tissue postprocessing for hydrogel preservation. Our intent is that the methods described herein can be helpful in the design and assessment of shear-thinning hydrogels for widespread biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.