Evidence map›Paper›PMID 29250559›Full record

ArticleJournal of immunology research2017

Beta-Defensin-2 and Beta-Defensin-3 Reduce Intestinal Damage Caused by

Alessandra Fusco, Vittoria Savio, Marcella Cammarota, Alberto Alfano, Chiara Schiraldi, Giovanna Donnarumma

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Combating Bacterial Infections with Vitamin D-Induced Antimicrobial Peptides.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. TwoInternational journal of molecular sciences · 2024
    Article
  10. Review
  11. Article
  12. Mechanisms and regulation of defensins in host defense.Signal transduction and targeted therapy · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Veterinary world · 2022
    Article
  19. Effects of Coated Sodium Butyrate and Polysaccharides FromFrontiers in veterinary science · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alessandra FuscoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio No. 7, 80138 Naples, Italy.ORCID 0000-0003-2641-1070
Vittoria SavioDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio No. 7, 80138 Naples, Italy.
Marcella CammarotaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio No. 7, 80138 Naples, Italy.
Alberto AlfanoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio No. 7, 80138 Naples, Italy.
Chiara SchiraldiDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio No. 7, 80138 Naples, Italy.
Giovanna DonnarummaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio No. 7, 80138 Naples, Italy.ORCID 0000-0002-3087-1240
University of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal microbiota is a major factor in human health and disease. This microbial community includes autochthonous (permanent inhabitants) and allochthonous (transient inhabitants) microorganisms that contribute to maintaining the integrity of the intestinal wall, modulating responses to pathogenic noxae and representing a key factor in the maturation of the immune system. If this healthy microbiota is disrupted by antibiotics, chemotherapy, or a change in diet, intestinal colonization by pathogenic bacteria or viruses may occur, leading to disease. To manage substantial microbial exposure, epithelial surfaces of the intestinal tract produce a diverse arsenal of antimicrobial peptides (AMPs), including, of considerable importance, the

Indexed as

beta-DefensinsCaco-2 CellsCell Culture TechniquesCytokinesEnterococcus faeciumGene Expression RegulationHumansImmunomodulationIntestinal MucosaMicrobiotaProbioticsSalmonella InfectionsSalmonella typhimuriumbeta-DefensinsCytokinesDEFB103A protein, humanDEFB4A protein, human

Identifiers

PMID29250559
PMCPMC5700477
OpenAlexW2767226645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.