ArticleChemosensors (Basel, Switzerland)2017
Illuminating Brain Activities with Fluorescent Protein-Based Biosensors.
Article in Chemosensors (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Advances in fluorescence-based point-of-care diagnostics: probes, nanostructures and integrated systems.Journal of materials chemistry. C · 2026Review
- Sampling Probes Microfabricated from Parylene‑C for In Vivo Neurochemical Monitoring.ACS measurement science au · 2025Article
- Using Biosensors to Detect and Map Language Areas in the Brain for Individuals with Traumatic Brain Injury.Diagnostics (Basel, Switzerland) · 2024Article
- Neuronal Activity Reporters as Drug Screening Platforms.Micromachines · 2022Review
- Review
- Imaging whole-brain activity to understand behavior.Nature reviews. Physics · 2022Article
- A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite.Cell chemical biology · 2021Article
- Bioluminescent Multi-Characteristic Opsin for Simultaneous Optical Stimulation and Continuous Monitoring of Cortical Activities.Frontiers in cellular neuroscience · 2021Article
- Live Imaging of Phosphate Levels in Arabidopsis Root Cells Expressing a FRET-Based Phosphate Sensor.Plants (Basel, Switzerland) · 2020Article
- Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia.Antioxidants (Basel, Switzerland) · 2020Review
- Understanding the Fluorescence Change in Red Genetically Encoded Calcium Ion Indicators.Biophysical journal · 2019Article
- Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43.Frontiers in cellular neuroscience · 2019Article
- Fluorescent Biosensors for Neurotransmission and Neuromodulation: Engineering and Applications.Frontiers in cellular neuroscience · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Fluorescent protein-based biosensors are indispensable molecular tools for life science research. The invention and development of high-fidelity biosensors for a particular molecule or molecular event often catalyze important scientific breakthroughs. Understanding the structural and functional organization of brain activities remain a subject for which optical sensors are in desperate need and of growing interest. Here, we review genetically encoded fluorescent sensors for imaging neuronal activities with a focus on the design principles and optimizations of various sensors. New bioluminescent sensors useful for deep-tissue imaging are also discussed. By highlighting the protein engineering efforts and experimental applications of these sensors, we can consequently analyze factors influencing their performance. Finally, we remark on how future developments can fill technological gaps and lead to new discoveries.
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Registered trials
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