Evidence map›Paper›PMID 29250438›Full record

ArticleMicromachines2017

Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications.

Chen S Tsai, Rong W Mao, Shirley C Tsai, Kaveh Shahverdi, Yun Zhu, Shih K Lin, Yu-Hsiang Hsu, Gerry Boss, Matt Brenner, Sari Mahon and 1 more

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Ultrasonic Levitation for Airway Humidification.Sensors (Basel, Switzerland) · 2024
    Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chen S TsaiDepartment of Electrical Engineering and Computer Science, University of California, Irvine, CA 92697, USA.
Rong W MaoDepartment of Electrical Engineering and Computer Science, University of California, Irvine, CA 92697, USA.
Shirley C TsaiDepartment of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697, USA.
Kaveh ShahverdiDepartment of Electrical Engineering and Computer Science, University of California, Irvine, CA 92697, USA.
Yun ZhuDepartment of Electrical Engineering and Computer Science, University of California, Irvine, CA 92697, USA.
Shih K LinDepartment of Electrical Engineering and Computer Science, University of California, Irvine, CA 92697, USA.
Yu-Hsiang HsuInstitute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan.
Gerry BossSchool of Medicine, University of Calfironia, San Diego, La Jolla, CA 92093, USA.
Matt BrennerDivision of Pulmonary and Critical Care Medicine, Beckman Laser Institute & Medical Clinics, School of Medicine, University of California, Irvine, CA 92697, USA.
Sari MahonDivision of Pulmonary and Critical Care Medicine, Beckman Laser Institute & Medical Clinics, School of Medicine, University of California, Irvine, CA 92697, USA.
Gerald C SmaldonePulmonary, Critical Care and Sleep Medicine Division, State University of New York at Stony Brook, New York, NY 11790, USA.
University of California, Irvine · USBeckman Laser Institute and Medical Clinic · USNational Taiwan University · TWState University of New York · US

Funding

Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying AgentU01NS058030 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2006 to 2017
$7.3M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2012 to 2017
$7.0M
ScientificU54NS063718 · NINDS · UNIVERSITY OF MINNESOTA · PI PATTERSON, STEVEN E · 2008 to 2011
$3.4M
MEMS-Based High-Frequency Ultrasonic Nozzles for Medical ApplicationsR21EB006366 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI TSAI, CHEN S · 2007 to 2008
$374k
NIBIB NIH HHS P41 EB015890NIBIB NIH HHS R21 EB006366NINDS NIH HHS U01 NS058030NINDS NIH HHS U54 NS063718
6 · The paper itself

Abstract

An in-depth review on a new ultrasonic micro-droplet generator which utilizes megahertz (MHz) Faraday waves excited by silicon-based multiple Fourier horn ultrasonic nozzles (MFHUNs) and its potential applications is presented. The new droplet generator has demonstrated capability for producing micro droplets of controllable size and size distribution and desirable throughput at very low electrical drive power. For comparison, the serious deficiencies of current commercial droplet generators (nebulizers) and the other ultrasonic droplet generators explored in recent years are first discussed. The architecture, working principle, simulation, and design of the multiple Fourier horns (MFH) in resonance aimed at the amplified longitudinal vibration amplitude on the end face of nozzle tip, and the fabrication and characterization of the nozzles are then described in detail. Subsequently, a linear theory on the temporal instability of Faraday waves on a liquid layer resting on the planar end face of the MFHUN and the detailed experimental verifications are presented. The linear theory serves to elucidate the dynamics of droplet ejection from the free liquid surface and predict the vibration amplitude onset threshold for droplet ejection and the droplet diameters. A battery-run pocket-size clogging-free integrated micro droplet generator realized using the MFHUN is then described. The subsequent report on the successful nebulization of a variety of commercial pulmonary medicines against common diseases and on the experimental antidote solutions to cyanide poisoning using the new droplet generator serves to support its imminent application to inhalation drug delivery.

Indexed as

clogging freeFaraday instabilityFaraday wavesintegrated ultrasonic nebulizerMFH ultrasonic nozzlemonodispersemultiple Fourier horns (MFH)onset threshold for droplet ejectionpolydispersepulmonary (inhalation) drug deliveryultrasonic micro droplet generatorultrasonic nebulizer

Identifiers

PMID29250438
PMCPMC5726552
OpenAlexW2588891134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.