Evidence map›Paper›PMID 29250300›Full record

ArticleOxidative medicine and cellular longevity2017

Cultivation and Immortalization of Human B-Cells Producing a Human Monoclonal IgM Antibody Binding to MDA-LDL: Further Evidence for Formation of Atherogenic MDA-LDL Adducts in Humans

Franz Tatzber, Edith Pursch, Ulrike Resch, Roswitha Pfragner, Sandra Holasek, Meinrad Lindschinger, Gerhard Cvirn, Willibald Wonisch

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Franz TatzberCenter of Molecular Medicine, Institute of Pathophysiology and Immunology, Medical University of Graz, Heinrichstrasse 31a, 8010 Graz, Austria.
Edith PurschInstitute of Biochemical Engineering, University of Applied Sciences Technikum-Wien, Höchstädtplatz 5-6, 1200 Vienna, Austria.
Ulrike ReschDepartment of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17/1, 1090 Vienna, Austria.
Roswitha PfragnerCenter of Molecular Medicine, Institute of Pathophysiology and Immunology, Medical University of Graz, Heinrichstrasse 31a, 8010 Graz, Austria.
Sandra HolasekCenter of Molecular Medicine, Institute of Pathophysiology and Immunology, Medical University of Graz, Heinrichstrasse 31a, 8010 Graz, Austria.
Meinrad LindschingerInstitute of Nutritional and Metabolic Diseases, Outpatient Clinic Laßnitzhöhe, Hauptstrasse 24/Top 21, 8301 Laßnitzhöhe, Austria.
Gerhard CvirnInstitute of Physiological Chemistry, Center for Physiological Medicine, Medical University of Graz, Stiftingtalstrasse 6 M1/D/3 8036, Graz, Austria.
Willibald WonischInstitute of Physiological Chemistry, Center for Physiological Medicine, Medical University of Graz, Stiftingtalstrasse 6 M1/D/3 8036, Graz, Austria.ORCID 0000-0001-7171-9539
Medical University of Graz · ATMedical University of Vienna · ATUniversity of Applied Sciences Technikum Wien · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidatively modified low-density lipoprotein (oLDL) is firmly believed to play an important role in the initiation and development of atherosclerosis, and malonic dialdehyde (MDA) is one of the major lipid peroxidation breakdown products involved in this process. In recent decades, antibodies against MDA-LDL have been detected in human and animal sera. In our study, human B-cells from the peripheral blood of a healthy female donor were fused with the SP2/0 mouse myeloma cell line. Antibody-producing hybridomas were detected by MDA-LDL-IgG/IgM enzyme-linked immunosorbent assays (ELISA) and Cu

Indexed as

AnimalsAutoantibodiesB-LymphocytesFemaleHumansImmunoglobulin MMaleMalondialdehydeMiceAutoantibodiesImmunoglobulin MMalondialdehyde

Identifiers

PMID29250300
PMCPMC5700503
OpenAlexW2767575498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.