Evidence map›Paper›PMID 29250029›Full record

ReviewFrontiers in neurology2017

Ischemic Strokes Due to Large-Vessel Occlusions Contribute Disproportionately to Stroke-Related Dependence and Death: A Review.

Konark Malhotra, Jeffrey Gornbein, Jeffrey L Saver

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 202 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 14 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04292600 completednot on this mapstarted 2021, after this paper: background citation

Testing of Identification Markers for Stroke

TypeobservationalSponsorPOCKiT diagnostics LtdRan2021 to 2023Enrolled383ConditionsStroke, Ischemic, Infarction, Middle Cerebral Artery, Infarction, Anterior Circulation, BrainArmsPOCKiT diagnostics' algorithm for LVO detection
NCT06910163 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Direct-to-angio Approach From loCal hOspitals Based on a PoInt-of-care bLOod Test for LVO (COPILOT): an Effectiveness Cluster Randomized Crossover Trial

TypeinterventionalSponsorJuan VicentyRan2025 to 2028Enrolled520ConditionsAcute StrokeArmsDiagnostic standard of care, LVOne Test
3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 14 syntheses or guidelines pooled it, 381 citations in OpenAlex.

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  10. Repeated mechanical thrombectomy for recurrent large vessel occlusion: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
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  16. Cilostazole versus clopidogrel in acute large-vessel moderate and moderate-to-severe ischemic stroke: a randomized controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  18. Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
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142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Konark MalhotraDepartment of Neurology, West Virginia University, Charleston Division, Charleston, WV, United States.
Jeffrey GornbeinDepartment of Biomathematics, University of California Los Angeles Comprehensive Stroke Center, Los Angeles, CA, United States.
Jeffrey L SaverDepartment of Neurology, University of California Los Angeles Comprehensive Stroke Center, Los Angeles, CA, United States.
University of California, Los Angeles · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince large-vessel occlusion (LVO)-related acute ischemic strokes (AIS) are associated with more severe deficits, we hypothesize that the endovascular thrombectomy (ET) may disproportionately benefit stroke-related dependence and death.

methodsTo delineate LVO-AIS impact, systematic search identified studies measuring dependence or death [modified Rankin Scale (mRS) 3-6] or mortality following ischemic stroke among consecutive patients presenting with both LVO and non-LVO events within 24 h of symptom onset.

resultsAmong 197 articles reviewed, 2 met inclusion criteria, collectively enrolling 1,467 patients. Rates of dependence or death (mRS 3-6) within 3-6 months were higher after LVO than non-LVO ischemic stroke, 64 vs. 24%, odds ratio (OR) 4.46 (CI: 3.53-5.63,

conclusionLVOs cause a little more than one-third of acutely presenting AIS, but are responsible for three-fifths of dependency and more than nine-tenths of mortality after AIS. At the population level, ET has a disproportionate benefit in reducing severe stroke outcomes.

Indexed as

endovascularischemicmorbiditystrokevessel occlusion

Identifiers

PMID29250029
PMCPMC5715197
OpenAlexW2775118070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.