Evidence map›Paper›PMID 29249973›Full record

ArticleFrontiers in physiology2017

Odorant Receptor 51E2 Agonist β-ionone Regulates RPE Cell Migration and Proliferation.

Nikolina Jovancevic, Soumaya Khalfaoui, Markus Weinrich, Daniel Weidinger, Annika Simon, Benjamin Kalbe, Marcus Kernt, Anselm Kampik, Günter Gisselmann, Lian Gelis and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
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  4. β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation.American journal of physiology. Lung cellular and molecular physiology · 2025
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  6. Review
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  11. Review
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  15. The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Ionone Is More than a Violet's Fragrance: A Review.Molecules (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Nikolina JovancevicCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Soumaya KhalfaouiCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Markus WeinrichCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Daniel WeidingerCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Annika SimonCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Benjamin KalbeCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Marcus KerntOphthalmology, Ludwig Maximilian University of Munich, Munich, Germany.
Anselm KampikOphthalmology, Ludwig Maximilian University of Munich, Munich, Germany.
Günter GisselmannCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Lian GelisCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Hanns HattCell Physiology, Ruhr-University Bochum, Bochum, Germany.
Ruhr University Bochum · DELudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The odorant receptor 51E2 (OR51E2), which is well-characterized in prostate cancer cells and epidermal pigment cells, was identified for the first time as the most highly expressed OR in human fetal and adult retinal pigment epithelial (RPE) cells. Immunofluorescence staining and Western blot analysis revealed OR51E2 localization throughout the cytosol and in the plasma membrane. Additionally, immunohistochemical staining of diverse layers of the eye showed that the expression of OR51E2 is restricted to the pigment cells of the RPE and choroid. The results of Ca

Indexed as

calcium imagingcell proliferationcell signalinggene expressionGPCR

Identifiers

PMID29249973
PMCPMC5714887
OpenAlexW2768738958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.