ArticleTranslational psychiatry2017
"DNA Methylation signatures in panic disorder".
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- A systematic review of methylome-wide associations with anxiety disorders.Translational psychiatry · 2026Pooled it
- Candidate Biological Markers for Social Anxiety Disorder: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Dynamics of Fear-Generalization Processes and Their Predictive Value for the Development of Anxiety-Related Psychopathology in Adolescents and Adults: A Study Protocol for a Longitudinal Study.International journal of methods in psychiatric research · 2026Article
- Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome.Molecular psychiatry · 2025Article
- A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice.Nature neuroscience · 2024Article
- Methylome-wide association study of anxiety disorders.Molecular psychiatry · 2023Article
- Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Maternal Epigenetic Dysregulation as a Possible Risk Factor for Neurodevelopmental Disorders.Genes · 2023Article
- Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma.Cancer research communications · 2023Article
- Epigenome-wide DNA methylation in obsessive-compulsive disorder.Translational psychiatry · 2022Article
- Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder.Clinical epigenetics · 2022Article
- Panic Attack Prediction Using Wearable Devices and Machine Learning: Development and Cohort Study.JMIR medical informatics · 2022Article
- DNA-methylation dynamics across short-term, exposure-containing CBT in patients with panic disorder.Translational psychiatry · 2022Article
- Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function.Frontiers in aging neuroscience · 2022Article
- The mediating role of transmembrane protein 132D methylation in predicting the occurrence of panic disorder in physical abuse.Frontiers in psychiatry · 2022Article
- From genetics to systems biology of stress-related mental disorders.Neurobiology of stress · 2021Article
- Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation.BMC genomics · 2021Article
- DNA methylation differences associated with social anxiety disorder and early life adversity.Translational psychiatry · 2021Article
- Altered immune phenotype and DNA methylation in panic disorder.Clinical epigenetics · 2020Article
- Genetic and epigenetic analyses of panic disorder in the post-GWAS era.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Panic disorder (PD) affects about four million Europeans, with women affected twice as likely as men, causing substantial suffering and high economic costs. The etiopathogenesis of PD remains largely unknown, but both genetic and environmental factors contribute to risk. An epigenome-wide association study (EWAS) was conducted to compare medication-free PD patients (n = 89) with healthy controls (n = 76) stratified by gender. Replication was sought in an independent sample (131 cases, 169 controls) and functional analyses were conducted in a third sample (N = 71). DNA methylation was assessed in whole blood using the Infinium HumanMethylation450 BeadChip. One genome-wide association surviving FDR of 5% (cg07308824, P = 1.094 × 10-7, P-adj = 0.046) was identified in female PD patients (N = 49) compared to controls (N = 48). The same locus, located in an enhancer region of the HECA gene, was also hypermethylated in female PD patients in the replication sample (P = 0.035) and the significance of the association improved in the meta-analysis (P-adj = 0.004). Methylation at this CpG site was associated with HECA mRNA expression in another independent female sample (N = 71) both at baseline (P = 0.046) and after induction by dexamethasone (P = 0.029). Of 15 candidates, 5 previously reported as associated with PD or anxiety traits also showed differences in DNA methylation after gene-wise correction and included SGK1, FHIT, ADCYAP1, HTR1A, HTR2A. Our study examines epigenome-wide differences in peripheral blood for PD patients. Our results point to possible sex-specific methylation changes in the HECA gene for PD but overall highlight that this disorder is not associated with extensive changes in DNA methylation in peripheral blood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.