Evidence map›Paper›PMID 29249828›Full record

ArticleTranslational psychiatry2017

Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data.

Tatiana Polushina, Sudheer Giddaluru, Francesco Bettella, Thomas Espeseth, Astri J Lundervold, Srdjan Djurovic, Sven Cichon, Per Hoffmann, Markus M Nöthen, Vidar M Steen and 2 more

Abstract read
In one paragraph

Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tatiana PolushinaNORMENT-K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Sudheer GiddaluruNORMENT-K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Francesco BettellaNORMENT-K.G. Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Thomas EspesethNORMENT-K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-9076-6365
Astri J LundervoldK.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Srdjan DjurovicNORMENT-K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Sven CichonDepartment of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland.
Per HoffmannDepartment of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-6573-983X
Markus M NöthenDepartment of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Vidar M SteenNORMENT-K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Ole A AndreassenNORMENT-K.G. Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Stéphanie Le HellardNORMENT-K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway. stephanie.hellard@uib.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have tested published methods for capturing allelic heterogeneity and identifying loci of joint effects to uncover more of the "hidden heritability" of schizophrenia (SCZ). We used two tools, cojo-GCTA and multi-SNP, to analyze meta-statistics from the latest genome-wide association study (GWAS) on SCZ by the Psychiatric Genomics Consortium (PGC). Stepwise regression on markers with p values <10

Indexed as

AllelesGenetic LociPolymorphism, Single NucleotideDatabases, GeneticGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansQuantitative Trait LociSchizophrenia

Identifiers

PMID29249828
PMCPMC5802566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.