Evidence map›Paper›PMID 29249812›Full record

ReviewNature reviews. Microbiology2018

Uncovering the mechanisms of Acinetobacter baumannii virulence.

Christian M Harding, Seth W Hennon, Mario F Feldman

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 575 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
575citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

575 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Drug-resistantClinical microbiology reviews · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Virulence · 2026
    Review
  7. Loss of CsrA inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Observational
  10. Article
  11. Review
  12. Article
  13. ISmLife · 2026
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. The population structure ofApplied and environmental microbiology · 2026
    Article

515 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christian M HardingDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.
Seth W HennonDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.
Mario F FeldmanDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.

Funding

INVESTIGATING TYPE VI SECRETION IN ACINETOBACTER BAUMANNII AND ITS INTERPLAY WITH ANTIBIOTIC RESISTAR01AI125363 · NIAID · WASHINGTON UNIVERSITY · PI FELDMAN, MARIO · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI125363
6 · The paper itself

Abstract

Acinetobacter baumannii is a nosocomial pathogen that causes ventilator-associated as well as bloodstream infections in critically ill patients, and the spread of multidrug-resistant Acinetobacter strains is cause for concern. Much of the success of A. baumannii can be directly attributed to its plastic genome, which rapidly mutates when faced with adversity and stress. However, fundamental virulence mechanisms beyond canonical drug resistance were recently uncovered that enable A. baumannii and, to a limited extent, other medically relevant Acinetobacter species to successfully thrive in the health-care environment. In this Review, we explore the molecular features that promote environmental persistence, including desiccation resistance, biofilm formation and motility, and we discuss the most recently identified virulence factors, such as secretion systems, surface glycoconjugates and micronutrient acquisition systems that collectively enable these pathogens to successfully infect their hosts.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsCross InfectionHumansVirulence

Identifiers

PMID29249812
PMCPMC6571207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.