Evidence map›Paper›PMID 29249695›Full record

ArticleCell chemical biology2018

GDC-0879, a BRAF

Jonas Sieber, Nicolas Wieder, Abbe Clark, Manuel Reitberger, Sofia Matan, Jeannine Schoenfelder, Jianming Zhang, Anna Mandinova, Joshua Adam Bittker, Juan Gutierrez and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Jonas SieberDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Nicolas WiederDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Abbe ClarkDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Manuel ReitbergerDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Sofia MatanDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Jeannine SchoenfelderDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Jianming ZhangDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Anna MandinovaDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Joshua Adam BittkerThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Juan GutierrezThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ozan AygünThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Namrata UdeshiThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Steven CarrThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Peter MundelDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Andreas Werner JehleDepartment of Biomedicine, Molecular Nephrology, University of Basel, Basel 4031, Switzerland.
Anna GrekaDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: agreka@bwh.harvard.edu.
Broad Institute · USHarvard University · USUniversity of Basel · CH

Funding

Role of B7-1 in Podocytes in Pathogenesis of ProteinuriaR01DK062472 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SOBERMAN, ROY · 2004 to 2017
$5.3M
Molecular mechanisms of podocyte injury in FSGSR01DK095045 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Anna Greka, Juan Lorenzo Pablo · 2014 to 2026
$5.1M
Role of TRPC5 channel inhibition in the treatment of glomerular diseaseR01DK099465 · NIDDK · BROAD INSTITUTE, INC. · PI Anna Greka · 2014 to 2026
$5.1M
CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODINR01DK057683 · NIDDK · YESHIVA UNIVERSITY · PI SOBERMAN, ROY · 2001 to 2015
$4.8M
Optimization of novel inhibitors of TRPC5 as anti-proteinuric therapeuticsR01DK103658 · NIDDK · VANDERBILT UNIVERSITY · PI HOPKINS, COREY R. · 2014 to 2018
$1.7M
Regulation of podocyte function by hic-5R01DK091218 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MUNDEL, PETER H · 2012 to 2015
$1.5M
NIDDK NIH HHS R01 DK057683NIDDK NIH HHS R01 DK062472NIDDK NIH HHS R01 DK091218NIDDK NIH HHS R01 DK095045NIDDK NIH HHS R01 DK099465NIDDK NIH HHS R01 DK103658
6 · The paper itself

Abstract

Progressive kidney diseases affect approximately 500 million people worldwide. Podocytes are terminally differentiated cells of the kidney filter, the loss of which leads to disease progression and kidney failure. To date, there are no therapies to promote podocyte survival. Drug repurposing may therefore help accelerate the development of cures in an area of tremendous unmet need. In a newly developed high-throughput screening assay of podocyte viability, we identified the BRAF

Indexed as

Cell DeathColforsinHumansIndenesKidney DiseasesMAP Kinase Signaling SystemPodocytesPyrazolesSignal TransductionThapsigargin2-(4-(1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)ethan-1-olColforsinIndenesPyrazolesThapsigarginBRAFcell deathERKER stressforskolinglomerular diseasekidney diseaseMAPKmelanomapost-mitotic cellsSB-682330

Identifiers

PMID29249695
PMCPMC5819995
OpenAlexW2771648208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.