Evidence map›Paper›PMID 29249689›Full record

ReviewCell metabolism2018

NAD

Jun Yoshino, Joseph A Baur, Shin-Ichiro Imai

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06005350 (Validation of an Enzymatic Assay for Quantification of Nicotinamide Adenine Dinucleotide in Blood Plasma After Ingestion of the Vitamin B3 Variant Nicotinamide Riboside), which is not on this map. Cited by 617 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
617citing papers in PubMed, 4 pooled it
32.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06005350 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Validation of an Enzymatic Assay for Quantification of Nicotinamide Adenine Dinucleotide in Blood Plasma After Ingestion of the Vitamin B3 Variant Nicotinamide Riboside: a Randomized Controlled Trial

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2023 to 2024Enrolled54ConditionsNADArmsNiagen, Placebo
3 · Its place in the literature

Who cites it

617 citing papers in PubMed, 4 syntheses or guidelines pooled it, 991 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Effects of NADThe Journal of pharmacology and experimental therapeutics · 2025
    Trial
  7. Trial
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The NADMolecular therapy. Oncology · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

557 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jun YoshinoCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address: jyoshino@wustl.edu.
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-114 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Building 421, Philadelphia, PA 19104-5160, USA. Electronic address: baur@pennmedicine.upenn.edu.
Shin-Ichiro ImaiDepartment of Developmental Biology, Department of Medicine (Joint), Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, USA; Japan Agency for Medical Research and Development, Project for Elucidating and Controlling Mechanisms of Aging and Longevity, Tokyo, Japan. Electronic address: imaishin@wustl.edu.
Japan Agency for Medical Research and Development · JPTranslational Therapeutics (United States) · USWashington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1M
REGULATION OF SYSTEMIC GLUCOSE AND LIPID HOMEOSTASIS BY ADIPOCYTE NAD BIOSYNTHESISR01DK104995 · NIDDK · WASHINGTON UNIVERSITY · PI KLEIN, SAMUEL · 2016 to 2024
$3.5M
ENAMPT-MEDIATED ADIPO-HYPOTHALAMIC COMMUNICATION FOR NAD+ PRODUCTION AND AGINGR01AG047902 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2014 to 2023
$3.2M
THE ROLE OF DORSOMEDIAL HYPOTHALAMIC NEURONS IN MAMMALIAN AGING AND LONGEVITYR01AG037457 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2011 to 2020
$3.1M
Molecular Mechanisms of Rapamycin's Effects on Health and LongevityR01AG043483 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2013 to 2017
$2.0M
NIA NIH HHS R01 AG037457NIA NIH HHS R01 AG043483NIA NIH HHS R01 AG047902NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK098656NIDDK NIH HHS R01 DK104995
6 · The paper itself

Abstract

Research on the biology of NAD

Indexed as

AgingAnimalsHumansNADNiacinamideNicotinamide MononucleotidePyridinium CompoundsNADNiacinamidenicotinamide-beta-ribosideNicotinamide MononucleotidePyridinium CompoundsagingmetabolismNAD(+)NAMPTnicotinamide adenine dinucleotidenicotinamide mononucleotidenicotinamide phosphoribosyltransferasenicotinamide ribosideNMNNMN adenylyltransferasesNMNATsNRNR kinasesNRKsPARPspoly-ADP-ribose polymerasessirtuins

Identifiers

PMID29249689
PMCPMC5842119
OpenAlexW2775008495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.