Evidence map›Paper›PMID 29249358›Full record

ArticleCell2018

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Mauro Gaya, Patricia Barral, Marianne Burbage, Shweta Aggarwal, Beatriz Montaner, Andrew Warren Navia, Malika Aid, Carlson Tsui, Paula Maldonado, Usha Nair and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 172 citations in OpenAlex.

  1. Trial
  2. Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Mauro GayaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; The Francis Crick Institute, London NW1A 1AT, UK. Electronic address: contact@maurogaya.com.
Patricia BarralThe Francis Crick Institute, London NW1A 1AT, UK; The Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, UK.
Marianne BurbageThe Francis Crick Institute, London NW1A 1AT, UK.
Shweta AggarwalThe Francis Crick Institute, London NW1A 1AT, UK.
Beatriz MontanerThe Francis Crick Institute, London NW1A 1AT, UK.
Andrew Warren NaviaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Institute for Medical Engineering & Science, MIT, Cambridge, MA 02139, USA; Broad Institute, Cambridge, MA 02142, USA.
Malika AidCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Carlson TsuiThe Francis Crick Institute, London NW1A 1AT, UK.
Paula MaldonadoThe Francis Crick Institute, London NW1A 1AT, UK.
Usha NairRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Khader GhneimCase Western Reserve University, Cleveland, OH 44106, USA.
Padraic G FallonInstitute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.
Rafick-Pierre SekalyCase Western Reserve University, Cleveland, OH 44106, USA.
Dan H BarouchRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Alex K ShalekRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Institute for Medical Engineering & Science, MIT, Cambridge, MA 02139, USA; Broad Institute, Cambridge, MA 02142, USA.
Andreas BruckbauerThe Francis Crick Institute, London NW1A 1AT, UK.
Jessica StridDivision of Immunology and Inflammation, Department of Medicine, Imperial College London, London W12 0NN, UK.
Facundo D BatistaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; The Francis Crick Institute, London NW1A 1AT, UK; Department of Microbiology and Immunobiology & HMS Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA. Electronic address: fbatista1@mgh.harvard.edu.
The Francis Crick Institute · GBRagon Institute of MGH, MIT and Harvard · USBeth Israel Deaconess Medical Center · USCase Western Reserve University · USBroad Institute · USHarvard University · USImperial College London · GBKing's College London · GBTrinity College Dublin · IE

Funding

Support Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BAROUCH, DAN H. · 2012 to 2018
$131.5M
Cancer Research UK FC001035Medical Research CouncilNIAID NIH HHS UM1 AI100663Wellcome Trust FC001035
6 · The paper itself

Abstract

B cells constitute an essential line of defense from pathogenic infections through the generation of class-switched antibody-secreting cells (ASCs) in germinal centers. Although this process is known to be regulated by follicular helper T (TfH) cells, the mechanism by which B cells initially seed germinal center reactions remains elusive. We found that NKT cells, a population of innate-like T lymphocytes, are critical for the induction of B cell immunity upon viral infection. The positioning of NKT cells at the interfollicular areas of lymph nodes facilitates both their direct priming by resident macrophages and the localized delivery of innate signals to antigen-experienced B cells. Indeed, NKT cells secrete an early wave of IL-4 and constitute up to 70% of the total IL-4-producing cells during the initial stages of infection. Importantly, the requirement of this innate immunity arm appears to be evolutionarily conserved because early NKT and IL-4 gene signatures also positively correlate with the levels of neutralizing antibodies in Zika-virus-infected macaques. In conclusion, our data support a model wherein a pre-TfH wave of IL-4 secreted by interfollicular NKT cells triggers the seeding of germinal center cells and serves as an innate link between viral infection and B cell immunity.

Indexed as

Immunity, InnateAnimalsB-LymphocytesChickensDogsGerminal CenterHumansInfluenza, HumanInterleukin-4Killer Cells, NaturalMacacaMacrophagesMadin Darby Canine Kidney CellsMiceMice, Inbred C57BLZika Virus InfectionInterleukin-4B cellsCXCR3germinal center seedingIL-4influenzalymph nodemacrophagesNKT cellsviral infectionZika virus

Identifiers

PMID29249358
PMCPMC5786505
OpenAlexW2773878006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.