Evidence map›Paper›PMID 29249332›Full record

ReviewTrends in genetics : TIG2018

Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression.

Qinyu Sun, Qinyu Hao, Kannanganattu V Prasanth

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 370 papers.

0numbers the graph read from it
0cells of the map it votes in
370citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

370 citing papers in PubMed.

  1. Measuring the Proximity of Nuclear lncRNAs to Nuclear Bodies.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Article
  3. ThebioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Intronic polyadenylation-derived long noncoding RNA modulates nucleolar integrity and function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Protein-Centric Mapping of RNA-DNA Interactions with RedChIP.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. The RNA NCell death & disease · 2025
    Article
  16. Article
  17. Unraveling LncRNAs: the future of lung cancer treatment.Journal of the Egyptian National Cancer Institute · 2025
    Review
  18. Article
  19. Review
  20. Article

310 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qinyu SunDepartment of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA; These authors contributing equally.
Qinyu HaoDepartment of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA; These authors contributing equally.
Kannanganattu V PrasanthDepartment of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA. Electronic address: kumarp@illinois.edu.

Funding

Characterization of nuclear retained RNA-mediated gene regulatory mechanismR01GM088252 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2011 to 2015
$1.4M
NIGMS NIH HHS R01 GM088252
6 · The paper itself

Abstract

A significant portion of the human genome encodes genes that transcribe long nonprotein-coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched on the chromatin or localized to specific subnuclear compartments. Nuclear lncRNAs participate in several biological processes, including chromatin organization, and transcriptional and post-transcriptional gene expression, and also act as structural scaffolds of nuclear domains. Here, we highlight recent studies demonstrating the role of lncRNAs in regulating gene expression and nuclear organization in mammalian cells. In addition, we update current knowledge about the involvement of the most-abundant and conserved lncRNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), in gene expression control.

Indexed as

Transcription, GeneticAnimalsCell NucleusChromatinChromosomal Proteins, Non-HistoneHumansNeoplasmsPolycomb-Group ProteinsRNA, Long NoncodingRNA Processing, Post-TranscriptionalTranscription FactorsX Chromosome InactivationChromatinChromosomal Proteins, Non-HistoneMALAT1 long non-coding RNA, humanPolycomb-Group ProteinsRNA, Long NoncodingSWI-SNF-B chromatin-remodeling complexTranscription Factors

Identifiers

PMID29249332
PMCPMC6002860

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.